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EGFR & ErbB-3

Anti-EGFR & ErbB-3 Products

Cetuximab (Gly-015CL)
- CAS number: 205923-56-4
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Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated) (Gly-055LC)
- Host Species: Human
- Specificity: Human
- Type: Chimeric antibody (mouse/human)
- Classification: Fc glycosylation/High-mannose glycosylated
- Glycosylation site: Asn297 in Fc region
- Glycoform (ratio): Man3GlcNAc2
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Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated) (Gly-055LC-1)
- Host Species: Human
- Specificity: Human
- Type: Chimeric antibody (mouse/human)
- Classification: Fc glycosylation/High-mannose glycosylated
- Glycosylation site: Asn297 in Fc region
- Glycoform (ratio): Man3GlcNAc2
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Recombinant Anti-Human EGFR Antibody (Fc glycosylation) (Gly-144LC)
- Host Species: Human
- Specificity: Human
- Type: Humanized antibody
- Classification: Fc glycosylation
- Glycosylation site: Asn297 in Fc region
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Recombinant Anti-Human EGFR Antibody (Non-glycosylated) (Gly-167LC)
- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Classification: Non-glycosylated
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For Research Use Only. Not For Clinical Use.

Background

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.

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Related Signaling Pathways

JAK-STAT Signaling Pathway