Cetuximab (CAT#: Gly-015CL)

Cetuximab is an epidermal growth factor receptor binding FAB. Cetuximab is composed of the Fv (variable; antigen-binding) regions of the 225 murine EGFr monoclonal antibody specific for the N-terminal portion of human EGFr with human IgG1 heavy and kappa light chain constant (framework) regions.


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  • Size:
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  • Purity:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Type
  • Biotech
  • Protein chemical formula
  • C6484H10042N1732O2023S36
  • Protein average weight
  • 145781.6 Da
  • CAS number
  • 205923-56-4
  • Class
  • Carboxylic Acids and Derivatives
  • Mechanism of action
  • Cetuximab binds to the epidermal growth factor receptor (EGFr) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers. Cetuximab competitively inhibits the binding of epidermal growth factor (EGF) and TGF alpha, thereby reducing their effects on cell growth and metastatic spread.

References

  • Synonyms
  • Cetuximab; Cétuximab; Cetuximab; Cetuximabum; Erbitux; Immunoglobulin G 1 (human-mouse monoclonal C 225 gamma 1 - chain anti-human epidermal growt factor receptor), disulfide wit human-mouse monoclonal C 225 kappa - chain, dimer
  • Genbank
  • J00228

Related Resources

  • Biosimilar Overview
  • Related Diseases
  • Related Signaling Pathways
Please refer to Cetuximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Cetuximab.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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