Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

Cetuximab (CAT#: Gly-015CL)

Cetuximab is an epidermal growth factor receptor binding FAB. Cetuximab is composed of the Fv (variable; antigen-binding) regions of the 225 murine EGFr monoclonal antibody specific for the N-terminal portion of human EGFr with human IgG1 heavy and kappa light chain constant (framework) regions.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/144_E9_2_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/143_E9_1_blue_red_green.jpg
Normal Tissue
Figure 3 Colon
Figure 3 Colon
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_9_3.jpg
Figure 4 Liver
Figure 4 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_7_4.jpg
Figure 5 Kidney
Figure 5 Kidney
(Bowman's capsule
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Collecting ducts
Staining:Medium
Intensity: Strong
Quantity: <25%
Distal tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Proximal tubules (cell body)
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_9_5.jpg
Figure 6 Testis
Figure 6 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_6_6.jpg
Figure 7 Placenta
Figure 7 Placenta
(Cytotrophoblasts
Staining:High
Intensity: Strong
Quantity:>75%
Decidual cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Hofbauer cells
Staining:High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - cell body
Staining:High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_1_7.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enriched (A-431)
Figure 9 RNA cell line category: Cell line enriched (A-431)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000146648-EGFR

Specifications

  • Type
  • Biotech
  • Protein chemical formula
  • C6484H10042N1732O2023S36
  • Protein average weight
  • 145781.6 Da
  • CAS number
  • 205923-56-4
  • Class
  • Carboxylic Acids and Derivatives
  • Mechanism of action
  • Cetuximab binds to the epidermal growth factor receptor (EGFr) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers. Cetuximab competitively inhibits the binding of epidermal growth factor (EGF) and TGF alpha, thereby reducing their effects on cell growth and metastatic spread.

References

  • Synonyms
  • Cetuximab; Cétuximab; Cetuximab; Cetuximabum; Erbitux; Immunoglobulin G 1 (human-mouse monoclonal C 225 gamma 1 - chain anti-human epidermal growt factor receptor), disulfide wit human-mouse monoclonal C 225 kappa - chain, dimer
  • Genbank
  • J00228

Related Resources

  • Biosimilar Overview
  • Related Diseases
  • Related Signaling Pathways
Please refer to Cetuximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Cetuximab.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "EGFR"

Select a product category from the dropdown menu below to view related products.
Please select product type
Chimeric Antibody Products Humanized Antibody Products Single Domain Antibody Products IgG Antibody Products Mouse Antibody Products Human Antibody Products Fc Glycosylation Antibody Products High-mannose Glycoform Antibody Products Deglycosylated Antibody Products Chicken IgY Antibody Products MHC Tetramer Products for Cancer Neutralizing Antibody Products Rabbit Monoclonal Antibody Products Fab Antibody Products ScFv Antibody Products ADCC Enhanced Antibody Products Antibody Magnetic Beads Cancer Stem Cell Biomarker Specific Antibody Products Non-Human Primate (NHP) Antibody Products ScFv-Fc Chimera Products Flow Cytometry (FC) related Products
CAT Product Name Application Type
TAB-H35 Anti-Human EGFR Recombinant Antibody (Futuximab) IF, WB, Inhib IgG1 - kappa
TAB-003 Anti-Human EGFR Recombinant Antibody (Cetuximab) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG1 - kappa
TAB-0225CL-S(P) Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-0225CL-S(P)) Block, Inhib, FuncS, Apop, In vivo Human scFv
PABX-051-F (E) Recombinant Mouse Anti-EGFR Antibody Fab Fragment (Matuzumab) WB, Neut, FuncS Fab
TAB-464CQ Anti-Human EGFR Recombinant Antibody (TAB-464CQ) ELISA, IHC, FC, IP, IF, FuncS IgG1, κ

Customer Reviews and Q&As

Submit a review or a question

There are currently no Customer reviews or questions for Gly-015CL. Click the button above to contact us or submit your feedback about this product.

Popular products with customers

Figure 1 Anti-ErbB2 Antibody (TAB-005) in WB

Anti-Human ErbB2 Recombinant Antibody (TAB-005) (CAT# TAB-005)
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC

Figure 1 Anti-Human CD22 Recombinant Antibody (TAB-176) in WB

Anti-Human CD22 Recombinant Antibody (TAB-176) (CAT# TAB-176)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 1 Anti-Human CD70 Recombinant Antibody (TAB-H76) in ELISA

Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) (CAT# TAB-H76)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 1 Anti-Human CD3 Therapeutic Antibody (TAB-019) in DB

Anti-Human CD3 Recombinant Antibody (TAB-019) (CAT# TAB-019)
Application: FC, IP, ELISA, Neut, FuncS, IF, WB

Figure 1 Mouse Anti-KIT Recombinant Antibody (PABL-642) in SDS-PAGE

Mouse Anti-KIT Recombinant Antibody (clone 79D) (CAT# PABL-642)
Application: WB, FuncS

Figure 3 Recombinant Human Anti-TSHR Antibody (PABW-172) in Dot Blot

Recombinant Human Anti-TSHR Antibody (M22) (CAT# PABW-172)
Application: WB, ELISA, PK

Figure 1 Human Anti-CD3 Recombinant Antibody (TAB-0416CL-S(P)) in SDS-PAGE

Mouse Anti-CD3 Recombinant Antibody scFv Fragment (TAB-0416CL-S(P)) (CAT# TAB-0416CL-S(P))
Application: IB, ELISA, FC, FuncS

Figure 1 Anti-Human CEACAM6 Recombinant Antibody (TAB-444LC) in ELISA

Anti-Human CEACAM6 Recombinant Antibody (TAB-444LC) (CAT# TAB-444LC)
Application: IHC, ELISA, FC, WB, ADCC, FuncS

Figure 1 Anti-Human TfR Recombinant Antibody (TAB-628CT) in SDS-PAGE

Anti-Human TfR Recombinant Antibody (3GH7 ) (CAT# TAB-628CT)
Application: WB

Figure 1 CCP Recombinant Antibody (TAB-390CQ) in SDS-PAGE

Anti-Human CCP Recombinant Antibody (F12) (CAT# TAB-390CQ)
Application: ELISA, IHC

Figure 1 Anti-Human CCP Recombinant Antibody (TAB-393CQ) in SDS-PAGE

Anti-Human CCP Recombinant Antibody (A02) (CAT# TAB-393CQ)
Application: ELISA, IHC

Figure 1 Anti-Human F8 Antibody in SDS-PAGE

Recombinant Human Anti-F8 Antibody (BO2C11) (CAT# PABX-058)
Application: WB, ELISA, FuncS, Inhib, PK, IP, SPR

Figure 1 Recombinant Mouse Anti-Integrin alpha 1 Antibody (PABX-121) in SDS-PAGE

Recombinant Mouse Anti-Integrin alpha 1 Antibody (AQC2) (CAT# PABX-121)
Application: WB, ELISA, Neut, FuncS

Figure 1 Anti-DPP4 Recombinant Antibody (HPAB-0215-YC) in WB

Human Anti-DPP4 Recombinant Antibody (HPAB-0215-YC) (CAT# HPAB-0215-YC)
Application: ELISA, Inhib, FuncS

Figure 1 Human Anti-IL15 Recombinant Antibody (HPAB-0238-YC) in ELISA

Human Anti-IL15 Recombinant Antibody (HPAB-0238-YC) (CAT# HPAB-0238-YC)
Application: ELISA, FC, Inhib, FuncS

Figure 1 Human IgG1, lambda Isotype Control Antibody (MOB-173CQ) in SDS-PAGE

Human IgG1, lambda Isotype Control Antibody (CAT# MOB-173CQ)
Application: ELISA

Figure 1 Mouse Anti-Histone Recombinant Antibody (FAMAB-0160YC) in SDS-PAGE

Mouse Anti-Histone Recombinant Antibody (clone LG2-1) (CAT# FAMAB-0160YC)
Application: IF

Figure 1 Recombinant Humanized Anti-Biotin Antibody (HPAB-0109-YJ) in WB

Human Anti-Biotin Recombinant Antibody (HPAB-0109-YJ) (CAT# HPAB-0109-YJ)
Application: SPR

Figure 1 Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0693-YC) in SDS-PAGE

Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0693-YC) (CAT# HPAB-M0693-YC)
Application: WB, FuncS

Figure 1 Human Anti-FZD5 Recombinant Antibody (PABJ-0145) in SDS-PAGE

Human Anti-FZD5 Recombinant Antibody (PABJ-0145) (CAT# PABJ-0145)
Application: ELISA, Inhib, FuncS

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

  • 0
  • 0
Cart
    Inquiry
    Go to compare

    Go to compare