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Plau

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This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, IHC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
IP, RIA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
FC, RIA, Biosensors, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, ELISA, FuncS
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Type:
Humanized Antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Type:
Humanized Antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Type:
Humanized Antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Phage display library
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, WB
Type:
Humanized Antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Mouse
Application:
ELISA, WB
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, IHC, FC, FuncS
Species Reactivity:
Human
Type:
Antibody
Targets:
Fibrin & PLAU
Type:
CrossMab
Application:
FuncS, Promising therapeutic agent
Urokinase (TP-050CL)
Protein Chemical Formula:
C1376H2145N383O406S18
Protein Average Weight:
31126.5 Da
CAS Number:
9039-53-6
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Derivation:
Phage display library
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, WB
Species Reactivity:
Human
Type:
IgG1, κ
Application:
WB, BL
Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
WB, IP, FC
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