Anti-PLAU (clone W24V75) Recombinant Antibody Coupled Liposome (VS-1024-FY76)
CAT#: VS-1024-FY76
The use of liposomes conjugated with anti-uPA antibodies represents a promising strategy in breast cancer treatment, as these specialized carriers can home in on specific cell receptors associated with cancer cells. By specifically targeting these receptors, the liposomes can enhance the effectiveness of the delivered therapeutic agents, ensuring that higher concentrations of the drug reach the intended site of action. This targeted approach not only improves the overall efficiency of drug delivery but also has the potential to minimize side effects, leading to better outcomes for patients undergoing breast cancer therapy.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1789_A4_1_cr5bacc2acbd568_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_2_7_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1886_D2_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/1819_G1_4_cr5bacc1ca11170_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_B_9_5.jpg
Normal Tissue
Figure 6 Colon
Endocrine cells
Staining:Medium
Intensity: Moderate
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Fibroblasts
Staining:High
Intensity: Strong
Goblet cells
Staining:Low
Intensity: Moderate
Quantity: <25%
Mucosal lymphoid cells
Staining:High
Intensity: Strong
Quantity:>75%
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_8_3.jpg
Normal Tissue
Figure 7 Kidney
Bowman's capsule
Staining:Medium
Intensity: Moderate
Quantity:>75%
Collecting ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Distal tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Proximal tubules (microvilli)
Staining:Medium
Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_9_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_5_6.jpg
Normal Tissue
Figure 9 Prostate
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70796/168931_A_2_5.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (CAPAN-2, LHCN-M2, RPTEC TERT1, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122861-PLAU
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer
Product Composition
- Clone
- W24V75
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This antibody is a human recombinant antibody specifically engineered to target and bind to human urokinase-type plasminogen activator (uPA). uPA is a crucial serine protease that plays a significant role in various physiological processes, including fibrinolysis, tissue remodeling, and cellular migration. By precisely interacting with uPA, this recombinant antibody holds the potential to modulate its activity, thereby influencing processes such as wound healing, inflammation, and cancer progression.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PLAU
- Introduction
- Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease found in humans and other animals. Human urokinase protein was discovered by McFarlane and Pilling in 1947, but it was not named. Urokinase was originally isolated from human urine and is also present in the extracellular matrix of blood and many tissues. The main physiological substrate of this enzyme is plasminogen, which is an inactive form of plasmin, a serine protease (zymogen). The activation of plasmin triggers a proteolytic cascade, depending on the physiological environment, and participates in thrombolysis or extracellular matrix degradation. This cascade is involved in vascular disease and cancer progression.
- Alternative Names
- PLAU; uPA; Urokinase-type plasminogen activator; Kinlytic; Abbokinase; ATF; BDPLT5; QPD; UPA; URK; u-PA; plasminogen activator; urokinase
- Full Name
- Urokinase
- Gene ID
- 5328
- UniProt ID
- P00749
- Cellular Localization
- Secreted
- Post Translation Modifications
- Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. ( P00749-UROK_HUMAN )
Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4. ( P00749-UROK_HUMAN )
Glycosylation at Thr38, Ser158, and Asn322 ( NX_P00749 [NX_P00749-1] )
Modification sites at PhosphoSitePlus ( P00749 )
Glycosylation from GlyConnect UROK_HUMAN (612, 86)
Glycosylation from GlyGen (P00749) 4 sites, 16 N-linked glycans (2 sites), 2 O-linked glycans (3 sites)
- Protein Refseq
- XP_011538168.1; XP_047281309.1; XP_054222066.1; XP_054222067.1; NP_001138503.2
- Function
- Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0275CL | Human Anti-PLAU Recombinant Antibody (TAB-0275CL) | FC, Inhib, FuncS | Humanized IgG |
| TAB-0275CL-S(P) | Human Anti-PLAU Recombinant Antibody; scFv Fragment (TAB-0275CL-S(P)) | FC, Inhib, FuncS | Humanized scFv |
| TAB-0277CL-S(P) | Human Anti-PLAU Recombinant Antibody; scFv Fragment (TAB-0277CL-S(P)) | FC, Inhib, FuncS | Humanized scFv |
| TAB-0275CL-F(E) | Human Anti-PLAU Recombinant Antibody; Fab Fragment (TAB-0275CL-F(E)) | FC, Inhib, FuncS | Humanized Fab |
| TAB-0277CL-F(E) | Human Anti-PLAU Recombinant Antibody; Fab Fragment (TAB-0277CL-F(E)) | FC, Inhib, FuncS | Humanized Fab |
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|---|---|---|---|
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| TAB-232CQ-F(E) | Human Anti-PLAU Recombinant Antibody; Fab Fragment (TAB-232CQ-F(E)) | ELISA, WB | Human Fab |
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