Anti-PLAU (clone W24V75) Recombinant Antibody Coupled Liposome (VS-1024-FY76) (CAT#: VS-1024-FY76)

• Potential Clinical Applications
• Breast cancer

• Clone
• W24V75

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This antibody is a human recombinant antibody specifically engineered to target and bind to human urokinase-type plasminogen activator (uPA). uPA is a crucial serine protease that plays a significant role in various physiological processes, including fibrinolysis, tissue remodeling, and cellular migration. By precisely interacting with uPA, this recombinant antibody holds the potential to modulate its activity, thereby influencing processes such as wound healing, inflammation, and cancer progression.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• PLAU

• Introduction
• Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease found in humans and other animals. Human urokinase protein was discovered by McFarlane and Pilling in 1947, but it was not named. Urokinase was originally isolated from human urine and is also present in the extracellular matrix of blood and many tissues. The main physiological substrate of this enzyme is plasminogen, which is an inactive form of plasmin, a serine protease (zymogen). The activation of plasmin triggers a proteolytic cascade, depending on the physiological environment, and participates in thrombolysis or extracellular matrix degradation. This cascade is involved in vascular disease and cancer progression.

• Alternative Names
• PLAU; uPA; Urokinase-type plasminogen activator; Kinlytic; Abbokinase; ATF; BDPLT5; QPD; UPA; URK; u-PA; plasminogen activator; urokinase

• Full Name
• Urokinase

• Gene ID
• 5328

• UniProt ID
• P00749

• Cellular Localization
• Secreted

• Post Translation Modifications
• Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. ( P00749-UROK_HUMAN )
  Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4. ( P00749-UROK_HUMAN )
  Glycosylation at Thr38, Ser158, and Asn322 ( NX_P00749 [NX_P00749-1] )
  Modification sites at PhosphoSitePlus ( P00749 )
  Glycosylation from GlyConnect UROK_HUMAN (612, 86)
  Glycosylation from GlyGen (P00749) 4 sites, 16 N-linked glycans (2 sites), 2 O-linked glycans (3 sites)

• Protein Refseq
• XP_011538168.1; XP_047281309.1; XP_054222066.1; XP_054222067.1; NP_001138503.2

• Function
• Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

Select a product category from the dropdown menu below to view related products.