Anti-PRKAA1 Recombinant Antibody Products

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Anti-PRKAA1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers advanced recombinantly produced antibodies targeting PRKAA1, designed to drive scientific breakthroughs with innovative design. Harnessing state-of-the-art technological platforms, including phage display and mammalian expression systems, we ensure each reagent delivers superior performance and consistent reliability, surpassing industry standards. Our comprehensive portfolio of recombinant immunoreagents is meticulously developed to meet diverse research needs, providing scientists with robust tools to explore novel discoveries. Moreover, we complement our high-quality products with personalized expert consultation, offering end-to-end support throughout every research stage. By integrating technical excellence with dedicated collaboration, we empower researchers to access cutting-edge solutions, fostering innovative advancements and elevating biomedical investigations to new frontiers.

PRKAA1: A Key Therapeutic Target for Multiple Diseases due to Its Role in Metabolic Regulation

PRKAA1, a serine/threonine kinase acting as a central hub in cellular signaling, plays a critical role in multiple pathological conditions by governing key biological processes linked to disease progression. In metabolic syndromes, this enzyme functions as a guardian of energy balance, orchestrating pathways that regulate glucose uptake, fatty acid oxidation, and mitochondrial function. When its activity is disrupted, cells fail to maintain optimal energy homeostasis, leading to insulin resistance, dyslipidemia, and the subsequent development of type 2 diabetes and obesity. In oncology, it influences tumor biology through dual mechanisms: under energy-deprived conditions, it promotes autophagy to sustain cancer cell survival, while in nutrient-rich environments, it can enhance anabolic pathways that drive uncontrolled proliferation. Such context-dependent roles make it a complex target in cancer therapy, as its modulation may either inhibit tumor growth or inadvertently support malignant progression. In neurodegenerative disorders, its dysfunction impairs axonal energy transport and disrupts the clearance of misfolded proteins, contributing to synaptic degeneration and the accumulation of toxic aggregates characteristic of Alzheimer’s and Parkinson’s diseases. Additionally, in cardiovascular diseases, altered activity of this kinase has been linked to myocardial energy deficit, compromising cardiac contractility and accelerating heart failure. By integrating signals from nutrient availability, stress responses, and cellular metabolism, this molecular regulator bridges multiple disease domains, highlighting its potential as a therapeutic target for interventions that address the underlying metabolic and signaling aberrations across diverse pathologies.

Alternative Names

Complement PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1

Background

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Anti-PRKAA1 rAb Products

We are dedicated to accelerating research and innovation by providing premium anti-PRKAA1 recombinant antibody products that combine superior quality, exceptional affordability, and unparalleled technical assistance, all aimed at supporting scientific advancements with robust solutions.

Table 1. Featured anti-PRKAA1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

To accelerate biopharmaceutical innovation from discovery to market success, we prioritize customer-centric principles, ensuring excellence in product performance and reliability. Our rigorous quality control framework is designed to consistently exceed industry standards, delivering solutions that streamline drug development timelines. By aligning with client needs and anticipating challenges, we empower researchers to achieve faster, more efficient commercialization of breakthrough therapies.

Customer Reviews

Excellent

Ju**r
Mouse Anti-PRKAA1 Recombinant Antibody (ZG-0285F) (CAT#: ZG-0285F)

The Mouse Anti-PRKAA1 Recombinant Antibody works well in WB using HEK293T lysates, detecting a clear band at the expected size. It also performs in IP assays with good specificity. Tested in mouse liver tissue, it shows minimal background. While it hasn’t been validated in IF/IHC, it’s reliable for basic PRKAA1 detection in lysate-based assays. A cost-effective option if you need consistent WB results.

16/Feb/2024

Excellent

O**ne
Recombinant Mouse Anti-PRKAA1 Monoclonal Antibody (B1-E10) (CAT#: MRO-0089-CN)

The Recombinant Mouse Anti-PRKAA1 antibody has worked well for IF in our lab. We've used it successfully in fixed HeLa cells, showing clear cytoplasmic staining with minimal background. It also performed adequately in mouse liver cryosections, though signal intensity varied slightly between samples. While we haven't tested it extensively in other applications, it's been reliable for our basic localization studies. The batch-to-batch consistency appears good based on our limited use.

11/Apr/2023

Excellent

Ca**n
Mouse Anti-PRKAA1 Recombinant Antibody (clone B1-E10) (CAT#: VS3-XY1296)

Mouse Anti-PRKAA1 has been useful for our IHC experiments on formalin-fixed paraffin-embedded mouse liver and kidney tissues. At 1:150 dilution, it produces specific nuclear and cytoplasmic staining that aligns with PRKAA1 expression patterns. The signal is clean with minimal background when using citrate-based antigen retrieval. We noticed slightly weaker staining in heart tissue samples. While it works consistently in mouse tissues, we haven't verified its cross-reactivity in other species. For the price, it's a decent option for basic murine tissue studies, though optimization may be needed for different fixation protocols.

22/Sep/2024

rAb Production

Leveraging accumulated years of specialized know-how in recombinant antibody development and optimization, we ensure delivery of premium-grade recombinant antibody products with exceptional quality standards, all through streamlined services that minimize turnaround time.

Featured Anti-PRKAA1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale recombinant antibody production.

Fig.3 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs specializes in providing researchers with a comprehensive selection of premium engineered antibodies, utilizing cutting-edge molecular design techniques. Our expertise spans diverse antibody development platforms, enabling us to deliver precisely customized solutions for unique research requirements. In addition to our standard offerings, we provide specialized modification services to optimize antibody performance for specific applications.

Fig.4 Full Length Anti-PRKAA1 Recombinant Antibody Production and Modalities.

For any inquiries about PRKAA1 research applications, our technical specialists are available to provide expert guidance. We welcome researchers to contact us through either communication channel for personalized assistance with experimental design or troubleshooting needs. Our team is committed to supporting your scientific investigations with tailored solutions.