+ Filter
Loading...
SMAD7
Loading...Anti-SMAD7 Products
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
Compare
- Mouse Anti-SMAD7 Recombinant Antibody (clone 3E3) (VS3-XY1437)
-
- Species Reactivity: Human
- Application: WB, IHC
Compare
- Human Anti-SMAD7 scFv-Fc Chimera (VS-0325-FY202) (VS-0325-FY202)
-
- Species Reactivity: Human
- Type: Human IgG1, scFv-Fc
- Application: ELISA, IF
Compare
- Anti-SMAD7 Immunohistochemistry Kit (VS-0325-XY2109)
-
- Species Reactivity: Human, Mouse, Rat
- Target: SMAD7
- Application: IHC
Compare
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
Compare
- Recombinant Anti-human SMAD7 Intrabody [(D-Arg)9] (IAB-B025(A))
-
- Species Reactivity: human
- Type: vhh-(D-Arg)9
- Application: FACS, ICC, FuncS
Compare
- Recombinant Anti-human SMAD7 Intrabody [+36 GFP] (IAB-B025(G))
-
- Species Reactivity: human
- Type: vhh-(+36GFP)
- Application: ELISA, ICC, FuncS
Compare
- Recombinant Anti-human SMAD7 Intrabody [Tat] (IAB-B025(T))
-
- Species Reactivity: human
- Type: vhh-Tat
- Application: PCA, Neut, FuncS
Compare
More Infomation
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Protein class
Disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Hepatic stellate cells, Distal enterocytes, Alveolar cells type 1)
Immune cell specificity
Immune cell enhanced (eosinophil, basophil)
Cell line specificity
Cell line enhanced (HDLM-2)
Interaction
Interacts with WWP1 (By similarity). Interacts with COPS5. Interacts with NEDD4L. Interacts with STAMBP. Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts (via MH2 domain) with EP300. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation. Interacts with PDPK1 (via PH domain).
Molecular function
DNA-binding
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway