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    Recombinant Anti-human SMAD7 Intrabody [+36 GFP] (CAT#: IAB-B025(G))

    Recombinant anti-SMAD7 intrabody in fusion with +36GFP works within cells to bind SMAD7, expressed in CHO cells. The intrabody relates to inhibito Smad7 expression or function for the preparation of a pharmaceutical composition for the prevention, amelioration or treatment of a disease of the central nervous system and/or diseases related and/or caused by said disease of the central nervous system.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nucleoli fibrillar center, cytosol & centrosome.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/28897/281_D12_4_selected.jpg
    Normal Tissue
    Figure 2 IHC staining of human lung
    Figure 2 IHC staining of human lung
    (Immunohistochemical staining of human lung shows moderate nuclear positivity.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/28897/ihc_selected.jpg
    Figure 3 IHC staining of human urinary bladder
    Figure 3 IHC staining of human urinary bladder
    (Immunohistochemical staining of human urinary bladder shows moderate nuclear positivity in urothelial cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/ihc_selected.jpg
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_B_8_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_A_9_3.jpg
    Figure 6 Liver
    Figure 6 Liver
    (Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_A_7_4.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_A_8_5.jpg
    Figure 8 Skin
    Figure 8 Skin
    (Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Keratinocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Langerhans Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_B_9_1.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
    Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000101665-SMAD7

    Specifications

    • Immunogen
    • human SMAD family member 7
    • Host Species
    • llama
    • Type
    • vhh-(+36GFP)
    • Cell Penetrating Peptide
    • +36 GFP
      GFP with a theoretical net charge of +36 (+36 GFP) penetrated several different mammalian cell lines at very low (nanomolar) concentrations. Cationic peptides and proteins have been observed to penetrate cells, and both natural and synthetic cell-penetrating peptides are widely used as delivery vehicles. However, whereas a covalent link between the cell-penetrating peptide and its cargo is typically required.
    • Species Reactivity
    • human
    • Applications
    • Antibody assay: Enzyme-linked Immunosorbent Assay; Immunocytochemistry; Functional studies

    Product Property

    • Purity
    • >97%, by SDS-PAGE under reducing conditions
    • Storage
    • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

    Target

    • Alternative Names
    • SMAD7; SMAD family member 7; CRCS3; MADH7; MADH8; mothers against decapentaplegic homolog 7; hSMAD7; MAD homolog 8; mothers against DPP homolog 8; SMAD, mothers against DPP homolog 7; Mothers against decapentaplegic, drosophila, homolog of, 7; MAD (mother

    Related Resources

    • Related Signaling Pathways

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "SMAD7"

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    IgG Antibody Products Intrabody Products Rabbit Monoclonal Antibody Products ScFv-Fc Chimera Products IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
    CAT Product Name Application Type
    MOB-4083z Mouse Anti-SMAD7 Recombinant Antibody (clone 21B4) WB, IP, IF, ELISA Mouse IgG1, κ
    MOB-1117CT Recombinant Mouse anti-Human SMAD7 Monoclonal antibody (EML551) IHC-P, WB
    VS3-XY1437 Mouse Anti-SMAD7 Recombinant Antibody (clone 3E3) WB, IHC

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