Anti-SMAD7 Immunohistochemistry Kit
CAT#: VS-0325-XY2109
Our SMAD7 IHC Kit is designed with simplicity in mind. All required reagents are included, and it is suitable for both paraffin and frozen sections. The antibodies in the kit are optimized to specifically bind to SMAD7, ensuring clear visualization and quantification of SMAD7 expression, which is important for understanding its role in negatively regulating TGF - β signaling and its significance in maintaining cellular homeostasis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nucleoli fibrillar center, cytosol & centrosome.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28897/281_D12_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human lung
Immunohistochemical staining of human lung shows moderate nuclear positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28897/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows moderate nuclear positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_A_7_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_A_8_5.jpg
Normal Tissue
Figure 8 Skin
Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Keratinocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Langerhans Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_B_9_1.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000101665-SMAD7
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Specifications
- Application
- IHC
- Size
- 50 Tests
- Species Reactivity
- Human, Mouse, Rat
- Target
- SMAD7
- Primary Antibody
- Mouse Anti-SMAD7 Monoclonal Antibody
- Secondary Antibody
- Goat anti-Mouse Antibody, HRP
- Sample Type
- FFPE tissue; Frozen section tissue
- Kit Storage
- All reagents should be kept at 2-8°C. The kit remains stable for up to 6 months after arrival.
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Related Signaling Pathways
TGF-β Signaling Pathway
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Datasheet
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Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "SMAD7"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4083z | Mouse Anti-SMAD7 Recombinant Antibody (clone 21B4) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| MOB-1117CT | Recombinant Mouse anti-Human SMAD7 Monoclonal antibody (EML551) | IHC-P, WB | |
| VS3-XY1437 | Mouse Anti-SMAD7 Recombinant Antibody (clone 3E3) | WB, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B025(A) | Recombinant Anti-human SMAD7 Intrabody [(D-Arg)9] | FACS, ICC, FuncS | vhh-(D-Arg)9 |
| IAB-B025(G) | Recombinant Anti-human SMAD7 Intrabody [+36 GFP] | ELISA, ICC, FuncS | vhh-(+36GFP) |
| IAB-B025(T) | Recombinant Anti-human SMAD7 Intrabody [Tat] | PCA, Neut, FuncS | vhh-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3325 | Hi-Affi™ Recombinant Rabbit Anti-SMAD7 Monoclonal Antibody (DS3325AB) | WB | IgG |
| MOR-4761 | Hi-Affi™ Recombinant Rabbit Anti-SMAD7 Monoclonal Antibody (TH275DS) | WB, IF, ICC, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY202 | Human Anti-SMAD7 scFv-Fc Chimera (VS-0325-FY202) | ELISA, IF | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6725 | Anti-Human SMAD7 Immunohistochemistry Kit | IHC |
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