Anti-SMAD7 Intrabody [(D-Arg)9] (IAB-B025(A))

Recombinant anti-SMAD7 intrabody linked to (D-Arg)9 works within cells and directs against SMAD7, expressed in CHO cells. The intrabody relates to inhibito Smad7 expression or function for the preparation of a pharmaceutical composition for the prevention, amelioration or treatment of a disease of the central nervous system and/or diseases related and/or caused by said disease of the central nervous system.      

human SMAD family member 7
Cell Penetrating Peptide
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
Formats of immunological tests: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies
Alternative Names
SMAD7; SMAD family member 7; CRCS3; MADH7; MADH8; mothers against decapentaplegic homolog 7; hSMAD7; MAD homolog 8
Entrez Gene ID
UniProt ID

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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