Recombinant Anti-human SMAD7 Intrabody [(D-Arg)₉] (CAT#: IAB-B025(A))

• Immunogen
• human SMAD family member 7

• Host Species
• llama

• Type
• vhh-(D-Arg)₉

• Cell Penetrating Peptide
• (D-Arg)₉
  It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.

• Species Reactivity
• human

• Applications
• Formats of immunological tests: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies

• Purity
• >95% as judged by SDS-polyacrylamide gel electrophoresis

• Storage
• 4 °C, -20°C if preferred

• Alternative Names
• SMAD7; SMAD family member 7; CRCS3; MADH7; MADH8; mothers against decapentaplegic homolog 7; hSMAD7; MAD homolog 8; mothers against DPP homolog 8; SMAD, mothers against DPP homolog 7; Mothers against decapentaplegic, drosophila, homolog of, 7; MAD (mother

• Gene ID
• 4092

• UniProt ID
• O15105

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