Disease related genes, Human disease related genes, Plasma proteins, Transcription factors
Intracellular
Low cell type specificity
Low immune cell specificity
Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)
Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation (PubMed:8605877, 28753426). Heterodimer with STAT2 upon IFN-alpha/beta induced phosphorylation (PubMed:8605877). The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9 (By similarity). Interacts (phosphorylated at Ser-727) with PIAS1; the interaction results in release of STAT1 from its target gene (PubMed:9724754, 17897103). Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466' (PubMed:9121453). Interacts with IFNAR2 (PubMed:9121453). Found in a complex with NMI and CREBBP/CBP (PubMed:9989503). Interacts with NMI which is required for CREBBP/CBP recruitment to the complex (PubMed:9989503). Interacts with PTK2/FAK1 (PubMed:11278462). Interacts with SRC (By similarity). Interacts with ERBB4 (phosphorylated) (PubMed:18721752). Interacts with PARP9 and DTX3L independently of IFN-beta or IFN-gamma-mediated STAT1 'Tyr-701' phosphorylation (PubMed:26479788). Interacts with histone acetyltransferase EP300/p300 in response to INF-gamma stimulation (PubMed:26479788). Interacts with OTOP1 (By similarity). Interacts with IFNGR1 (PubMed:8156998). (Microbial infection) Interacts with Sendai virus C', C, Y1 and Y2 proteins, preventing activation of ISRE and GAS promoter. (Microbial infection) Interacts with Nipah virus P, V and W proteins preventing activation of ISRE and GAS promoter. (Microbial infection) Interacts with Rabies virus phosphoprotein preventing activation of ISRE and GAS promoter. (Microbial infection) Interacts with HCV core protein; the interaction results in STAT1 degradation. (Microbial infection) Interacts with ebolavirus protein VP24.
Activator, DNA-binding
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For Research Use Only. Not For Clinical Use.