CytoStream™ Rabbit Anti-STAT1 Recombinant Antibody (VS13-YC1117)
CAT#: VS13-YC1117
The CytoStream™ Rabbit Anti-STAT1 Recombinant Antibody is specific for human STAT1. STAT1, a STAT family member, activates transcription in response to cytokines/growth factors, involved in immune responses to pathogens, with homo- and heterodimer formation. The anti-STAT1 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows cytoplasmic positivity in non-germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/931/2258_A_7_8_selected.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/931/2258_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/931/2258_A_6_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/931/2258_A_7_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115415-STAT1/subcellular
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Specifications
- Immunogen
- Recombinant human STAT1 alpha, aa 1-50.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human STAT1
- Species Reactivity
- Human
- Applications
- WB, ICC, IF, IHC-P, IP, FC
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/5000
Immunocytochemistry (ICC): 1/100-1/500
Immunofluorescence (IF): 1/100-1/500
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- STAT91, ISGF-3
- Gene ID
- 6772
- UniProt ID
- P42224
- Long Name
- Signal Transducer And Activator Of Transcription 1
- Sequence Similarities
- Belongs to the transcription factor STAT family.
- Cellular Localization
- Nucleus; Cytoplasm
- Protein Refseq
- NP_009330.1; NP_644671.1
- Function
- Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN- stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
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Related Signaling Pathways
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "STAT1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2429z | Mouse Anti-STAT1 Recombinant Antibody (clone 13A1) | WB, ICC, IF, IHC | Mouse IgG1 |
| MRO-1434-CN | Recombinant Mouse Anti-STAT1 Monoclonal Antibody (G3-B11) | WB, IF, IHC | Mouse IgG2b |
| MRO-1435-CN | Recombinant Rabbit Anti-STAT1 Monoclonal Antibody (CBACN-527) | WB, IP, FC | Rabbit IgG |
| ZG-113R | Mouse Anti-STAT1 Recombinant Antibody (ZG-113R) | WB | Mouse IgG |
| ZG-0580U | Rabbit Anti-Phospho-STAT1 (S727) Recombinant Antibody (clone 2H10) | ELISA, WB, IHC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0563MZ | Chicken Anti-STAT1 (ab1) Polyclonal IgY | WB | Chicken antibody |
| BRD-0564MZ | Chicken Anti-STAT1 (ab2) Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3425 | Hi-Affi™ Recombinant Rabbit Anti-STAT1 Monoclonal Antibody (DS3425AB) | WB | IgG |
| MOR-4710 | Hi-Affi™ Recombinant Rabbit Anti-STAT1 Monoclonal Antibody (TH224DS) | WB, IF, ICC, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0335 | APC-A*02:01/Human STAT-1 (VLWDRTFSL) MHC Tetramer | FCM | |
| MHC-CN0336 | PE-A*02:01/Human STAT-1 (VLWDRTFSL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY248 | AbPlus™ Anti-STAT1 Magnetic Beads (CBACN-527) | IP, Protein Purification | |
| VS-0724-YC962 | AbPlus™ Anti-STAT1 Magnetic Beads (VS-0724-YC962) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY492 | Rabbit Anti-NHP STAT1 Recombinant Antibody (VS-1024-XY492) | WB, IHC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1116 | CytoStream™ Rabbit Anti-STAT1 Recombinant Antibody (VS13-YC1116) | WB, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2193 | Anti-STAT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6947 | Anti-Mouse STAT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6946 | Anti-Human STAT1 Immunohistochemistry Kit | IHC |
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