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TFPI

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For Research Use Only. Not For Clinical Use.


Background

Tissue factor pathway inhibitor is a single-chain polypeptide which can reversibly inhibit factor Xa. While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex.
TFPI
Protein class

Candidate cardiovascular disease genes, FDA approved drug targets, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts, Syncytiotrophoblasts, Hepatic stellate cells)

Immune cell specificity

Group enriched (basophil, plasmacytoid DC, neutrophil)

Cell line specificity

Cell line enhanced (HHSteC, HUVEC TERT2, LHCN-M2, TIME)

Molecular function

Protease inhibitor, Serine protease inhibitor

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