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    TFPI

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
    TFPI
    Protein class

    Candidate cardiovascular disease genes, FDA approved drug targets, Plasma proteins

    Predicted location

    Secreted

    Single cell type specificity

    Cell type enhanced (Extravillous trophoblasts, Syncytiotrophoblasts, Hepatic stellate cells)

    Immune cell specificity

    Group enriched (basophil, plasmacytoid DC, neutrophil)

    Cell line specificity

    Cell line enhanced (HHSteC, HUVEC TERT2, LHCN-M2, TIME)

    Molecular function

    Protease inhibitor, Serine protease inhibitor

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