Anti-TFPI Recombinant Antibody (Concizumab)
CAT#: TAB-734
Recombinant humanized antibody expressed in CHO binding to human TFPI. Concizumab is a monoclonal IgG4 antibody (mAb) that binds to the Kunitz-type protease inhibitor (KPI) 2 domain of TFPI thereby blocking the interaction of this domain with the active site of FXa.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human smooth muscle
Immunohistochemical staining of human smooth muscle shows distinct positivity in endothelial.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5575/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows distinct cytoplasmic positivity in endothelium.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_4_6.jpg
Normal Tissue
Figure 6 Placenta
Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_2_7.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HUVEC TERT2, LHCN-M2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003436-TFPI
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- undefined
- Derivation
- Humanized
- Type
- IgG4 - kappa
- Species Reactivity
- Human
- Applications
- ELISA, IP, FC, FuncS, Neut, IF, WB, PK
- Generic Name
- concizumab
- Related Disease
- Hemophilia
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Applications
- Application Notes
- The TFPI antibody has been reported in applications of ELISA, IP, FC, FuncS, Neut, IF, WB, PK.
Target
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Versatile Application Possibilities
The versatility of Concizumab is notable; it performs well across a variety of applications, including WB, ELISA, and flow cytometry. This flexibility has allowed us to use the same antibody in multiple settings, reducing the need for different reagents.
Invaluable in Hemophilia Research
As hemophilia researchers, Concizumab has supported our investigations into clotting pathways as a reliable tool to study the effects of TFPI inhibition, which enables us to reveal new therapeutic possibilities.
Excellent Technical Support
The support provided by Creative Biolabs has been excellent. Their readiness to assist with technical questions ensures smooth experimental setups and optimal antibody performance.
Q&As
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What applications can Concizumab be used in?
A: Concizumab is versatile and can be used in various applications, including ELISA, immunoprecipitation (IP), flow cytometry (FC), functional studies (FuncS), neutralization (Neut), immunofluorescence (IF), and Western blot (WB).
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How does Concizumab function in research?
A: Concizumab is a monoclonal IgG4 antibody. It binds to the Kunitz-type protease inhibitor (KPI) 2 domain of TFPI, pQAenting its interaction with the active site of factor Xa (FXa), thus effectively modulating the coagulation process in study settings.
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How should Concizumab be stored for optimal activity?
A: Store Concizumab at -20°C to maintain its stability and efficacy. It's important to avoid multiple freeze-thaw cycles to preserve its integrity.
View the frequently asked questions answered by Creative Biolabs Support.
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Biosimilar Overview
Please refer to Concizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Concizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Concizumab"
Afuco™ Anti-TFPI ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-734)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human TFPI. It is a monoclonal IgG4 antibody (mAb) that binds to the Kunitz-type protease inhibitor (KPI) 2 domain of TFPI thereby blocking the interaction of this domain with the active site of FXa.
DrugMonitor™ Anti-Concizumab Antibody (VS-1224-YC301)Concizumab has participated in trials for treating hemophilia A and congenital bleeding disorders. The DrugMonitor™ Anti-Concizumab Antibody (VS-1224-YC301) is an anti-drug antibody (ADA) against Concizumab. This drug-based antibody is raised in mice immunized with the Concizumab. The anti-Concizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Concizumab in samples.
See other products for "TFPI"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-711 | Human Anti-TFPI Recombinant Antibody (clone mAb 2021); Fab Fragment | Block | Human Fab |
| HPAB-2587LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2587LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2588LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2588LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2589LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2589LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2590LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2590LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2015CT | Recombinant Mouse anti-Human TFPI Monoclonal antibody (5H5) | ELISA, WB | |
| HPAB-0428-YC | Human Anti-TFPI Recombinant Antibody (clone TFPI-106) | ELISA, FC, FuncS | Human IgG |
| HPAB-0429-YC | Human Anti-TFPI Recombinant Antibody (clone TFPI-118) | ELISA, FC, FuncS | Human IgG |
| HPAB-0431-YC | Human Anti-TFPI Recombinant Antibody (HPAB-0431-YC) | ELISA, FC, FuncS | Chimeric (mouse/human) IgG1 |
| HPAB-2598LY | Human Anti-TFPI Recombinant Antibody (HPAB-2598LY) | ELISA, WB, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3547 | Rabbit Anti-TFPI Recombinant Antibody (clone DS3547AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0488-CN-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0488-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-0489-CN-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0489-CN-S(P)) | ELISA, FC | Human scFv |
| PSBC-539 | Human Anti-TFPI Recombinant Antibody (clone ch2F22); scFv Fragment | ELISA, FC, Neut | Mouse scFv |
| HPAB-2597LY-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-2597LY-S(P)) | ELISA, WB, FuncS | Human scfv |
| HPAB-2598LY-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-2598LY-S(P)) | ELISA, WB, FuncS | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-734 | Afuco™ Anti-TFPI ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-734) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC647 | AbPlus™ Anti-TFPI Magnetic Beads (VS-0724-YC647) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY189 | Human Anti-TFPI (clone Concizumab) scFv-Fc Chimera | ELISA, FC | Human IgG4, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7198 | Anti-TFPI Immunohistochemistry Kit | IHC |
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