Anti-TFPI Recombinant Antibody (Concizumab) (CAT#: TAB-734)
Recombinant humanized antibody expressed in CHO binding to human TFPI. Concizumab is a monoclonal IgG4 antibody (mAb) that binds to the Kunitz-type protease inhibitor (KPI) 2 domain of TFPI thereby blocking the interaction of this domain with the active site of FXa.
Specific Inquiry
PK
Figure 1 PK result of the antibody.
Mean PK profiles of concizumab concentration (log scale) up to 43 days after i.v. and s.c. administration of concizumab or placebo to healthy volunteers and hemophilia patients.
Chowdary, P., Lethagen, S., Friedrich, U., Brand, B., Hay, C., Abdul Karim, F.,... & Miesbach, W. (2015). Safety and pharmacokinetics of anti‐TFPI antibody (concizumab) in healthy volunteers and patients with hemophilia: a randomized first human dose trial. Journal of Thrombosis and Haemostasis, 13(5), 743-754.
ELISA
Figure 2 ELISA result of the antibody.
Mean free TFPI plasma concentration (ng mL−1) evaluated by TFPI ELISA up to 43 days after i.v. and s.c. administration of concizumab or placebo to healthy volunteers and hemophilia patients.
Chowdary, P., Lethagen, S., Friedrich, U., Brand, B., Hay, C., Abdul Karim, F.,... & Miesbach, W. (2015). Safety and pharmacokinetics of anti‐TFPI antibody (concizumab) in healthy volunteers and patients with hemophilia: a randomized first human dose trial. Journal of Thrombosis and Haemostasis, 13(5), 743-754.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- undefined
- Derivation
- Humanized
- Type
- IgG4 - kappa
- Species Reactivity
- Human
- Applications
- ELISA, IP, FC, FuncS, Neut, IF, WB, PK
- Generic Name
- concizumab
- Related Disease
- Hemophilia
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Applications
- Application Notes
- The TFPI antibody has been reported in applications of ELISA, IP, FC, FuncS, Neut, IF, WB, PK.
Target
- Alternative Names
- concizumab;mAb 2021;4F110 ;TFPI;tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor);LACI;tissue factor pathway inhibitor;EPI;extrinsic pathway inhibitor;TFI;TFPI1;anti-convertin;
- Gene ID
- 7035
- UniProt ID
- P10646
Related Resources
Please refer to Concizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Concizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Concizumab"
Afuco™ Anti-TFPI ADCC Recombinant Antibody (Concizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human TFPI. Concizumab is a monoclonal IgG4 antibody (mAb) that binds to the Kunitz-type protease inhibitor (KPI) 2 domain of TFPI thereby blocking the interaction of this domain with the active site of FXa.
See other products for "TFPI"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-718 | Human Anti-TFPI Recombinant Antibody (clone mAb 2021) | Block | Human IgG |
| PABC-461 | Mouse Anti-TFPI Recombinant Antibody (PABC-461) | FuncS, ELISA, FC, Neut | Mouse IgG1, κ |
| HPAB-2592LY | Human Anti-TFPI Recombinant Antibody (HPAB-2592LY) | ELISA, WB, FuncS | Human IgG |
| HPAB-2593LY | Human Anti-TFPI Recombinant Antibody (HPAB-2593LY) | ELISA, WB, FuncS | Human IgG |
| HPAB-2594LY | Human Anti-TFPI Recombinant Antibody (HPAB-2594LY) | ELISA, WB, FuncS | Human IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3547 | Rabbit Anti-TFPI Recombinant Antibody (clone DS3547AB) | WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0488-CN-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0488-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-0495-YJ-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0495-YJ-S(P)) | ELISA, WB, FuncS | Human scFv |
| HPAB-0496-YJ-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0496-YJ-S(P)) | ELISA, WB, FuncS | Human scFv |
| HPAB-0591-YJ-S(P) | Mouse Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0591-YJ-S(P)) | ELISA, FC, Neut, FuncS | Mouse scFv |
| HPAB-0592-YJ-S(P) | Mouse Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0592-YJ-S(P)) | ELISA, FC | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0429-YC-F(E) | Human Anti-TFPI Recombinant Antibody (clone TFPI-118); Fab Fragment | ELISA, FC, FuncS | Human Fab |
| HPAB-0431-YC-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-0431-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-2619LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2619LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2620LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2620LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2621LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2621LY-F(E)) | ELISA, WB, FuncS | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-734 | Afuco™ Anti-TFPI ADCC Recombinant Antibody (Concizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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