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10-FnIII anti-MSTN (SFN-L016)

The tenth fibronectin type III domain (10Fn3) that bound myostatin was isolated from the library using mRNA display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=0.76 nM) for myostatin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      
Datasheet
Specifications
Scaffold Name
10-FnIII
Origin
Fibronectin
Core Structure
β-sandwich of 7 β-strands
Variable Regions
2–3 Loops
Target
Myostatin
Species Reactivity
Human
Expression Host
BL21 (DE3) cells
Affinity Constant
0.76 nM
Applications
ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
Alternative Names
Fibronectin; 10-FnIII; GDF8; MSLHP
Entrez Gene ID
2660
UniProt ID
O14793

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Anti-Human MSTN Therapeutic Antibody scFv Fragment (Ab2)    ( TAB-451MZ-S(P) )
Anti-Human MSTN Therapeutic Antibody (H0L0)    ( TAB-457MZ )
Anti-Human MSTN Therapeutic Antibody Fab Fragment (H4H1657N2)    ( TAB-0496CL-F(E) )
Anti-Human MSTN Therapeutic Antibody scFv Fragment (22-E6)    ( TAB-0481CL-S(P) )
Anti-Human MSTN Therapeutic Antibody (2_112_K)    ( TAB-460MZ )
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