10-FnIII scaffold protein anti-Human Myostatin

Name: 10-FnIII scaffold protein anti-Human Myostatin
SKU: SFN-L016
Rating: 5 (1 reviews)

CAT#: SFN-L016

The tenth fibronectin type III domain (10Fn3) that bound myostatin was isolated from the library using mRNA display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=0.76 nM) for myostatin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.

Gene Expression

Normal Tissue Figure 1 IHC staining of human skeletal muscle

Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (LHCN-M2, RH-30)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN

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Specifications

Scaffold Name
10-FnIII

Origin
Fibronectin

Core Structure
β-sandwich of 7 β-strands

Variable Regions
2–3 Loops

Target
Myostatin

Species Reactivity
Human

Expression Host
BL21 (DE3) cells

Affinity Constant
0.76 nM

Applications
ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

Target

Alternative Names
Fibronectin; 10-FnIII; GDF8; MSLHP

Gene ID
2660

UniProt ID
O14793

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Datasheet

Datasheet - SFN-L016.pdf

MSDS

MSDS - SFN-L016.pdf

COA

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