10-FnIII scaffold protein anti-Human Myostatin (CAT#: SFN-L016)
The tenth fibronectin type III domain (10Fn3) that bound myostatin was isolated from the library using mRNA display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=0.76 nM) for myostatin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human skeletal muscle
(Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg
(Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg
Figure 2 RNA cell line category: Group enriched (LHCN-M2, RH-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN
Specifications
- Scaffold Name
- 10-FnIII
- Origin
- Fibronectin
- Core Structure
- β-sandwich of 7 β-strands
- Variable Regions
- 2–3 Loops
- Target
- Myostatin
- Species Reactivity
- Human
- Expression Host
- BL21 (DE3) cells
- Affinity Constant
- 0.76 nM
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
Downloads
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Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0476CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0476CL) | ELISA, WB | Mouse IgG |
| TAB-0477CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0477CL) | ELISA, WB | Mouse IgG |
| TAB-0478CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0478CL) | ELISA, WB | Mouse IgG |
| TAB-0479CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0479CL) | ELISA, WB | Mouse IgG |
| TAB-0480CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0480CL) | ELISA, WB | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-451MZ | Human Anti-MSTN Recombinant Antibody (TAB-451MZ) | FuncS, Inhib | Humanized IgG4 |
| TAB-457MZ | Anti-Human MSTN Recombinant Antibody (H0L0) | ELISA, FuncS, Inhib | Humanized antibody |
| TAB-458MZ | Anti-Human MSTN Recombinant Antibody (H1L2) | ELISA | Humanized antibody |
| TAB-459MZ | Anti-Human MSTN Recombinant Antibody (H2L2) | ELISA, FuncS, Inhib | Humanized antibody |
| TAB-451MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-451MZ-S(P)) | ELISA | Humanized scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-456MZ | Anti-Human MSTN Recombinant Antibody (10B3C) | FuncS, Inhib | Chimeric antibody (mouse/human) |
| TAB-456MZ-S(P) | Anti-Human MSTN Recombinant Antibody scFv Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
| TAB-456MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-452MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-452MZ-F(E)) | ELISA | Human Fab |
| TAB-453MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-453MZ-F(E)) | ELISA | Human Fab |
| TAB-454MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (F1-10) | SDS-PAGE, WB, ELISA | Human antibody |
| TAB-460MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-460MZ-F(E)) | ELISA | Human Fab |
| TAB-461MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-461MZ-F(E)) | ELISA | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0268CQ-S(P) | Mouse Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0268CQ-S(P)) | ELISA, Neut | Mouse scFv |
| HPAB-0269CQ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0269CQ-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0058-YJ-S(P) | Mouse Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0058-YJ-S(P)) | ELISA, Neut, IP | Mouse scFv |
| HPAB-0493-FY-S(P) | Mouse Anti-MSTN Recombinant Antibody (clone BP6b- 6); scFv Fragment | Inhib | Mouse scFv |
| HPAB-0494-FY-S(P) | Mouse Anti-MSTN Recombinant Antibody (clone BPla-1); scFv Fragment | ELISA | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0056-WJ | Human Anti-MSTN Recombinant Antibody (HPAB-0056-WJ) | ELISA, WB | Humanized IgG1, κ |
| HPAB-AP389-YC | Human Anti-MSTN Recombinant Antibody (HPAB-AP389-YC) | ELISA, Neut | Humanized IgG |
| HPAB-AP390-YC | Human Anti-MSTN Recombinant Antibody (HPAB-AP390-YC) | ELISA, Neut | Humanized IgG |
| HPAB-AP391-YC | Human Anti-MSTN Recombinant Antibody (HPAB-AP391-YC) | ELISA, Neut | Humanized IgG |
| HPAB-AP392-YC | Human Anti-MSTN Recombinant Antibody (HPAB-AP392-YC) | ELISA, Neut | Humanized IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0276LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0276LY-F(E)) | ELISA, Neut, in vivo effect | Humanized Fab |
| HPAB-0277LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0277LY-F(E)) | ELISA | Humanized Fab |
| HPAB-0278LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0278LY-F(E)) | ELISA | Humanized Fab |
| HPAB-0279LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0279LY-F(E)) | ELISA | Humanized Fab |
| HPAB-0280LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0280LY-F(E)) | ELISA | Humanized Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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