Anti-Human MSTN Recombinant Antibody (H0L0) (CAT#: TAB-457MZ)

This antibody which binds to myostatin can be potentially used in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.


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  • Gene Expression
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FuncS

Figure 1 shows binding of the HOLO humanised anti-myostatin antibody to myostatin following treatment of the antibody with or without ammonium bicarbonate which can induce deamidation of the antibody.

Figure 1 shows binding of the HOLO humanised anti-myostatin antibody to myostatin following treatment of the antibody with or without ammonium bicarbonate which can induce deamidation of the antibody.

Inhib

Figure 3 shows the H2L2-N54Q, H2L2-C91S, H2L2-N54Q-C91S humanised anti-myostatin antibody variants, H0L0, H2L2 and 10B3C inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.

Figure 3 shows the H2L2-N54Q, H2L2-C91S, H2L2-N54Q-C91S humanised anti-myostatin antibody variants, H0L0, H2L2 and 10B3C inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.

ELISA

Figure 4 shows the binding of purified H2L2-N54Q, H2L2-C91S, H2L2- N54Q-C91S humanised anti-myostatin antibody variants, H2L2, HOLO and 10B3C (HCLC) to myostatin by ELISA.

Figure 4 shows the binding of purified H2L2-N54Q, H2L2-C91S, H2L2- N54Q-C91S humanised anti-myostatin antibody variants, H2L2, HOLO and 10B3C (HCLC) to myostatin by ELISA.

Inhib

Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.

Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.


Specifications

  • Host Species
  • Human
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Clone
  • H0L0
  • Applications
  • ELISA, FuncS, Inhib
  • Related Disease
  • Muscle atrophy

Applications

  • Application Notes
  • This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Functional Assay, Inhibition.

Target

  • Alternative Names
  • MSTN; myostatin; GDF8; MSLHP; growth/differentiation factor 8; GDF-8; growth differentiation factor 8

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-2313z Mouse Anti-MSTN Recombinant Antibody (clone 19F12) WB, ELISA, FC, ICC, IF, IHC Mouse IgG2b
HPAB-0268CQ Mouse Anti-MSTN Recombinant Antibody (HPAB-0268CQ) ELISA, Neut, FuncS Mouse IgG
HPAB-0269CQ Human Anti-MSTN Recombinant Antibody (HPAB-0269CQ) ELISA, Neut Human IgG
HPAB-0270CQ Mouse Anti-MSTN Recombinant Antibody (HPAB-0270CQ) ELISA, FC, DB, Block, IA, FuncS Mouse IgG
HPAB-0271CQ Human Anti-MSTN Recombinant Antibody (HPAB-0271CQ) ELISA, FC, DB, Block Human IgG1

Chimeric Antibody

CAT Product Name Application Type
TAB-456MZ Anti-Human MSTN Recombinant Antibody (10B3C) FuncS, Inhib Chimeric antibody (mouse/human)
TAB-456MZ-S(P) Anti-Human MSTN Recombinant Antibody scFv Fragment (10B3C) ELISA Chimeric antibody (mouse/human)
TAB-456MZ-F(E) Anti-Human MSTN Recombinant Antibody Fab Fragment (10B3C) ELISA Chimeric antibody (mouse/human)

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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