AbPlus™ Anti-MSTN Magnetic Beads (VS-0424-XY191) (CAT#: VS-0424-XY191)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magrose bead (> 50 μmol/mL gel)

• Bead Ligand
• Anti-MSTN specific antibody

• Target
• MSTN

• Immunogen
• Purified human mature MSTN protein

• Target Species
• Human

• Bead Capacity
• 20-30 mg/mL binding antibody

• Bead size
• 10-37 μm

• Stability
• pH 2-14

• Format
• 20% Suspension

• Buffer
• PBS, pH 7.4, with 1% BSA

• Preservative
• 0.03% Proclin 300

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• MSTN is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The preproprotein of MSTN is proteolytically processed to generate each subunit of the disulfide-linked homodimer. MSTN negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in MSTN are associated with increased skeletal muscle mass in humans and other mammals.

• Alternative Names
• Myostatin; GDF8; Growth Differentiation Factor 8; Growth/Differentiation Factor 8; MSLHP; GDF-8; JA-16

• Gene ID
• 2660

• UniProt ID
• O14793

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