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    MSTN

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]
    MSTN
    Protein class

    Disease related genes, Human disease related genes

    Predicted location

    Secreted

    Single cell type specificity

    Cell type enhanced (Muller glia cells, Early spermatids, Bipolar cells, Late spermatids, Cone photoreceptor cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Group enriched (LHCN-M2, RH-30)

    Interaction

    Homodimer; disulfide-linked (PubMed:27625211). Interacts with WFIKKN2, leading to inhibit its activity (PubMed:12595574). Interacts with FST3 (PubMed:17878677).

    Molecular function

    Cytokine, Growth factor, Heparin-binding

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