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MSTN

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
MSTN
Protein class

Disease related genes, Human disease related genes

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Muller glia cells, Early spermatids, Bipolar cells, Late spermatids, Cone photoreceptor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (LHCN-M2, RH-30)

Interaction

Homodimer; disulfide-linked (PubMed:27625211). Interacts with WFIKKN2, leading to inhibit its activity (PubMed:12595574). Interacts with FST3 (PubMed:17878677).

Molecular function

Cytokine, Growth factor, Heparin-binding

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