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MSTN

Antibody-like Scaffold Protein Products Antibody Magnetic Beads AbPlus Recombinant Antibody Products Formats

Anti-MSTN Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


MSTN is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The preproprotein of MSTN is proteolytically processed to generate each subunit of the disulfide-linked homodimer. MSTN negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in MSTN are associated with increased skeletal muscle mass in humans and other mammals.
MSTN
Protein class

Disease related genes, Human disease related genes

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Muller glia cells, Early spermatids, Bipolar cells, Late spermatids, Cone photoreceptor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (LHCN-M2, RH-30)

Interaction

Homodimer; disulfide-linked (PubMed:27625211). Interacts with WFIKKN2, leading to inhibit its activity (PubMed:12595574). Interacts with FST3 (PubMed:17878677).

Molecular function

Cytokine, Growth factor, Heparin-binding

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