Anti-EphA2 (clone 1C1)-mc-MMAF ADC (CAT#: ADC-028LZY)

• Antibody Overview
• Human Anti-EphA2 IgG1,1C1

• Clone
• 1C1

• Antibody Isotype
• IgG1

• Linker
• mc (maleimidocaproyl)

• Linker Class/Description
• Class: Noncleavable linker
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation

• Drug
• MMAF (monomethyl auristatin F)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]

• Alternative Names
• EPHA2; EPH receptor A2; ECK; CTPA; ARCC2; CTPP1; CTRCT6; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase;

• Gene ID
• 1969

• UniProt ID
• A0A024QZA8

• ADC-113LCT
• Anti-EphA2 receptor (1C1)-vcMMAE ADC

• ADC-L023
• Anti-EhpA2 (1C1)-Mc-MMAF ADC (MEDI-547)

• PABL-083
• Human Anti-EPHA2 Recombinant Antibody (clone 1C1)

• PSBL-083
• Human Anti-EPHA2 Recombinant Antibody (clone 1C1); scFv Fragment

• PFBL-083
• Human Anti-EPHA2 Recombinant Antibody (clone 1C1); Fab Fragment

• VS-0724-XY26
• Human Anti-EPHA2 Agonistic Antibody (clone 1C1)

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