APC-A*02:01/Human INS (ALWGPDPAAA) MHC Tetramer
CAT#: MHC-LC1683
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of INS-derived peptide of ALWGPDPAAA covering 15-24 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Pancreas
Pancreatic endocrine cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4932/115849_A_1_3.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (EFO-21, U-2 OS, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000254647-INS
❮
❯
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- INS
- Antigen Species
- Human
- Peptide
- ALWGPDPAAA
- Range
- 15-24
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
- Alternative Names
- INS; insulin; IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
- Gene ID
- 3630
- UniProt ID
- P01308
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Effective Insulin Specific Staining
This A*02:01 tetramer loaded with the INS peptide ALWGPDPAAA was crucial for our diabetes research. The APC label gave a good signal, and we were able to detect insulin-specific CD8 T cells in our human samples with high specificity.
Robust Tool For Beta Cell Study
We used this reagent to investigate autoimmune responses to insulin. The tetramer performed consistently, allowing us to characterize the phenotype of antigen-specific T cells targeting pancreatic beta cells. The product quality is reliable.
Q&As
-
What is the biological role of the INS gene product?
A: The INS gene encodes insulin, a peptide hormone produced by beta cells of the pancreatic islets. Insulin regulates blood glucose levels by facilitating glucose uptake into cells. It is a key autoantigen in Type 1 Diabetes.
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What peptide sequence does this tetramer present?
A: This HLA-A*02:01 tetramer presents the peptide sequence ALWGPDPAAA, which corresponds to amino acids 15-24 of the human Insulin protein. It is used to detect insulin-specific CD8 T cells.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "INS"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1554-VHH | Recombinant Anti-human INS VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1026 | Mouse Anti-INS Recombinant Antibody (clone YC182); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0152MZ | Recombinant Mouse Anti-Insulin/Proinsulin Antibody (clone E7C5) | ELISA, IHC-Fr | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC905 | PE-A*02:01/Human INS (AQWGPDPAAA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC962 | PE-DRB1*04:01/Human INS (GSLQPLALEGSLQKRG) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC977 | PE-H2-K1/Human INS (LYLVCGERG) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC980 | PE-H2-K1/Human INS (LYLVCGERV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC983 | PE-H2-K1/Human INS (LYLVCGERGF) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1841 | Rabbit Anti-INS Recombinant Antibody (clone DS1841AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4627 | Rabbit Anti-INS Recombinant Antibody (clone TH140DS) | IF, ICC, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0182YC | Mouse Anti-INS Recombinant Antibody (clone 123) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0183YC | Mouse Anti-INS Recombinant Antibody (clone 124) | ELISA | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0184YC | Mouse Anti-INS Recombinant Antibody (clone 133) | ELISA | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0185YC | Mouse Anti-INS Recombinant Antibody (clone 125) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0182-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 123); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0183-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 124); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0184-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 133); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0185-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 125); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0186-YC-S(P) | Mouse Anti-INS Recombinant Antibody (clone 127); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0182-YC-F(E) | Mouse Anti-INS Recombinant Antibody (clone 123); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0183-YC-F(E) | Mouse Anti-INS Recombinant Antibody (clone 124); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0184-YC-F(E) | Mouse Anti-INS Recombinant Antibody (clone 133); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0185-YC-F(E) | Mouse Anti-INS Recombinant Antibody (clone 125); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF029 | DRB1*04:01/Human Proinsulin (GAGSLQPLALEGSLQKRG) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF032 | DRB1*04:01/Human Proinsulin (GIVEQCCTSICSLYQ) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF236 | A*02:01/Human Ins B. 10 (HLVEALYLV) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3566 | Anti-INS Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3567 | Anti-Mouse INS Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3568 | Anti-Rat INS Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC112 | Recombinant Anti-INS (α chain x β chain) Biparatopic Antibody, Tandem scFv (Clone AE9D6 x Clone CB5) | ELISA | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC195 | Recombinant Anti-INS Eliminating Antibody, pH-Sensitive (5ins16 var.) | Antigen-Sweeping In Vivo. | Human IgG |
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