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  • Anti-Human ADAMTS5 Recombinant Antibody Fab Fragment (CRB0124)

Anti-Human ADAMTS5 Recombinant Antibody Fab Fragment (CRB0124) (CAT#: TAB-0701CLV-F(E))

The anti-Sp_ADAMTS-5 antibody specifically binds to ADAMTS5 which is kind of aggrecanases of which the activities can result in the degradation of the cartilage matrix. By binding to the ADAMTS-5, the antibody can be used for the treatment of cartilage degradation, osteoarthritis and rheumatoid arthritis.

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Subcellular Location
Figure 1 IF staining of human cell line RH-30
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30906/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human caudate
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in glial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5661/ihc_selected.jpg
Figure 3 IHC staining of human fallopian tube
Figure 3 IHC staining of human fallopian tube
(Immunohistochemical staining of human fallopian tube shows strong positivity in cytoplasm and cilia of glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/ihc_selected.jpg
Figure 4 Colon
Figure 4 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_3.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_8_5.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_4_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, RH-30, U-87 MG)
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, RH-30, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000154736-ADAMTS5

Specifications

  • Immunogen
  • Sp_ADAMTS-5
  • Host Species
  • Human
  • Type
  • Human antibody
  • Specificity
  • Human
  • Clone
  • CRB0124
  • Related Disease
  • Cartilage degradation, osteoarthritis, rheumatoid arthritis

Target

  • Alternative Names
  • ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif, 5; ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Select a product category from the dropdown menu below to view related products.
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Fab Antibody Products ScFv Antibody Products Mouse Antibody Products Chimeric Antibody Products Humanized Antibody Products IgG Antibody Products
CAT Product Name Application Type
MOB-39-F(E) Recombinant Anti-human ADAMTS5 Antibody Fab Fragment ELISA, IP, FuncS Fab
MHH-39-F(E) Recombinant Human Anti-human ADAMTS5 Antibody Fab Fragment IF, FC, FuncS Fab
PFBL-391 Mouse Anti-ADAMTS5 Recombinant Antibody; Fab Fragment (PFBL-391) WB, ELISA, FuncS Mouse Fab
HPAB-AP227-YC-F(E) Mouse Anti-ADAMTS5 Recombinant Antibody; Fab Fragment (HPAB-AP227-YC-F(E)) ELISA Mouse Fab
HPAB-AP228-YC-F(E) Human Anti-ADAMTS5 Recombinant Antibody; Fab Fragment (HPAB-AP228-YC-F(E)) ELISA Human Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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