Anti-Human ADAMTS5 Recombinant Antibody (3A12.1D7) (CAT#: TAB-0688CLV)
The anti-ADAMTS5 antibody 3A12.1D7 targets ADAMTS5 that is kind of aggrecanases of which the activities can result in the degradation of the cartilage matrix. By inhibiting ADAMTS5 and thereby reducing the breakdown of extracellular matrix aggrecan in cartilage and other tissues, 3A12.1D7 can be used in the treatment of disease of cartilage.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30906/if_selected.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30906/if_selected.jpg
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in glial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5661/ihc_selected.jpg
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in glial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5661/ihc_selected.jpg
Figure 3 IHC staining of human fallopian tube
(Immunohistochemical staining of human fallopian tube shows strong positivity in cytoplasm and cilia of glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/ihc_selected.jpg
(Immunohistochemical staining of human fallopian tube shows strong positivity in cytoplasm and cilia of glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/ihc_selected.jpg
Figure 4 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_3.jpg
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_3.jpg
Figure 5 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_8_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_8_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_4_6.jpg
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_4_6.jpg
Figure 7 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, RH-30, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000154736-ADAMTS5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000154736-ADAMTS5
Specifications
- Immunogen
- ADAMTS4, ADAMTS5
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Cross-react with cynomolgus and canine ADAMTS5
- Clone
- 3A12.1D7
- Related Disease
- Diseases of cartilage
Target
- Alternative Names
- ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif, 5; ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11
- Gene ID
- 11096
- UniProt ID
- Q9UNA0
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-39-F(E) | Recombinant Anti-human ADAMTS5 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| MHH-39-F(E) | Recombinant Human Anti-human ADAMTS5 Antibody Fab Fragment | IF, FC, FuncS | Fab |
| PFBL-005 | Mouse Anti-ADAMTS5 Recombinant Antibody (clone 7B4); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| PFBL-391 | Mouse Anti-ADAMTS5 Recombinant Antibody; Fab Fragment (PFBL-391) | WB, ELISA, FuncS | Mouse Fab |
| HPAB-AP227-YC-F(E) | Mouse Anti-ADAMTS5 Recombinant Antibody; Fab Fragment (HPAB-AP227-YC-F(E)) | ELISA | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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