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    Anti-Human ADAMTS5 Recombinant Antibody scFv Fragment (7B4.1E11) (CAT#: TAB-0685CLV-S(P))

    The anti-ADAMTS5 antibody 7B4.1E11 targets ADAMTS5 that is kind of aggrecanases of which the activities can result in the degradation of the cartilage matrix. By inhibiting ADAMTS5 and thereby reducing the breakdown of extracellular matrix aggrecan in cartilage and other tissues, the antibody can be used in the treatment of disease of cartilage.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line RH-30
    Figure 1 IF staining of human cell line RH-30
    (Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30906/if_selected.jpg
    Normal Tissue
    Figure 2 IHC staining of human caudate
    Figure 2 IHC staining of human caudate
    (Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in glial cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5661/ihc_selected.jpg
    Figure 3 IHC staining of human fallopian tube
    Figure 3 IHC staining of human fallopian tube
    (Immunohistochemical staining of human fallopian tube shows strong positivity in cytoplasm and cilia of glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/ihc_selected.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Glandular cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_3.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Cells in tubules
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_8_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_4_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, RH-30, U-87 MG)
    Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, RH-30, U-87 MG)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000154736-ADAMTS5

    Specifications

    • Immunogen
    • ADAMTS4, ADAMTS5
    • Host Species
    • Mouse
    • Specificity
    • Human
    • Species Reactivity
    • Cross-react with cynomolgus and canine ADAMTS5
    • Clone
    • 7B4.1E11
    • Related Disease
    • Diseases of cartilage

    Target

    • Alternative Names
    • ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif, 5; ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    See other products for "ADAMTS5"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibody Products Fab Antibody Products ScFv Antibody Products Mouse Antibody Products Chimeric Antibody Products Humanized Antibody Products Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
    CAT Product Name Application Type
    MOB-39 Recombinant Anti-human ADAMTS5 Antibody ELISA, WB, Dot, FuncS IgG
    MHH-39 Recombinant Human Anti-human ADAMTS5 Antibody ELISA, WB, FC, FuncS IgG
    PABL-005 Mouse Anti-ADAMTS5 Recombinant Antibody (clone 7B4) Inhib, WB, ELISA, FuncS Mouse IgG1
    PABL-391 Mouse Anti-ADAMTS5 Recombinant Antibody (PABL-391) WB, ELISA, FuncS Mouse IgG2c
    MOB-142CQ Mouse Anti-ADAMTS5 Recombinant Antibody (clone CBLS-195) ELISA, WB, IP Mouse IgG2b

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