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BMP2
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Basal keratinocytes, Alveolar cells type 2, Distal enterocytes, Suprabasal keratinocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (CACO-2, HeLa, hTERT-HME1, RT4)
Interaction
Homodimer; disulfide-linked (PubMed:10074410). Interacts with SOSTDC1 (PubMed:15020244). Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). Interacts with MAFP5 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631). Interacts with type I receptor BMPR1A (PubMed:15064755). Interacts with type II receptor BMPR2 (PubMed:7791754). Interacts with SCUBE3 (PubMed:33308444). Interacts with TNFAIP6 (primarily via Link domain); this interaction is inhibited by hyaluronan.
Molecular function
Cytokine, Developmental protein, Growth factor
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway
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- Species Reactivity: Human
- Type: Mouse IgG2
- Application: IHC-P, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IHC
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IF
- Mouse Anti-BMP2 Recombinant Antibody (clone CBL720) (NEUT-050CQ)
-
- Species Reactivity: Zebrafish
- Type: Mouse IgG1
- Application: Neut, WB
- Rabbit Anti-BMP2 Polyclonal Antibody (MRO-1697-CN) (MRO-1697-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF
- Human Anti-BMP2 Recombinant Antibody (clone 11F2) (HPAB-0170-YC)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC, IHC, WB, Block
- Human Anti-BMP2 Recombinant Antibody (clone 8B3) (HPAB-0169-YC)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC, IHC, WB, Block
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
- Human Anti-BMP2 Recombinant Antibody (clone 11F2); Fab Fragment (HPAB-0170-YC-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, IHC, WB
- Human Anti-BMP2 Recombinant Antibody (clone 8B3); Fab Fragment (HPAB-0169-YC-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, IHC, WB
- Human Anti-BMP2 Recombinant Antibody (clone 11F2); scFv Fragment (HPAB-0170-YC-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, IHC, WB
- Human Anti-BMP2 Recombinant Antibody (clone 8B3); scFv Fragment (HPAB-0169-YC-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, IHC, WB
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For Research Use Only. Not For Clinical Use.