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    Human Anti-CD3 (clone YTH 12.5) scFv-Fc Chimera

    CAT#: VS-0125-FY56

    The anti-CD3 scFv-Fc is a human-derived single-chain antibody fragment designed to specifically bind to CD3, a critical component of the T-cell receptor complex. By effectively recruiting and activating immune cells at tumor sites, this engineered antibody fragment holds great promise for advancing cancer immunotherapy and optimizing therapeutic outcomes for patients.

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Antibody Isotype
    • scFv-Fc
    • Species Reactivity
    • Human
    • Clone
    • YTH 12.5
    • Applications
    • ELISA, Flow Cytometry
    • Related Disease
    • Cancer

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Stabilizer
    • No Stabilizers
    • Sterility
    • 0.2 μM filtered
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • The potential function of anti-CD3 scFv-Fc may be to enhance the cytotoxicity of T cells against tumor cells through their activation, resulting in improved anti-tumor effects.

    Target

    • Alternative Names
    • Cluster of differentiation 3; CD3
    • Cellular Localization
    • Cell membrane
    • Post Translation Modifications
    • Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
      Phosphorylated also by PKC; leading to the TCR complex down-regulation.
      Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
      Glycosylation at Asn52 and Asn92
      Ubiquitination at Lys32, Lys79, Lys93, Lys95, Lys150, and Lys164
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyGen 2 sites
    • Function
    • Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.
      When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.
      All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.
      Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.
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    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - VS-0125-FY56.pdf

    MSDS

    MSDS - VS-0125-FY56.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

    Secondary Antibody

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