Human Anti-CD3 (clone YTH 12.5) scFv-Fc Chimera
CAT#: VS-0125-FY56
The anti-CD3 scFv-Fc is a human-derived single-chain antibody fragment designed to specifically bind to CD3, a critical component of the T-cell receptor complex. By effectively recruiting and activating immune cells at tumor sites, this engineered antibody fragment holds great promise for advancing cancer immunotherapy and optimizing therapeutic outcomes for patients.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- YTH 12.5
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The potential function of anti-CD3 scFv-Fc may be to enhance the cytotoxicity of T cells against tumor cells through their activation, resulting in improved anti-tumor effects.
Target
- Alternative Names
- Cluster of differentiation 3; CD3
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
Phosphorylated also by PKC; leading to the TCR complex down-regulation.
Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
Glycosylation at Asn52 and Asn92
Ubiquitination at Lys32, Lys79, Lys93, Lys95, Lys150, and Lys164
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites
- Protein Refseq
- XP_005271781.1; XP_006719004.1; XP_054226470.1; NP_000064.1
- Function
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.
When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.
All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.
Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone YTH 12.5"
- CAT
- Product Name
See other products for "CD3"
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