Human Anti-CD3 (clone YTH 12.5) scFv-Fc Chimera (CAT#: VS-0125-FY56)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• YTH 12.5

• Applications
• ELISA, Flow Cytometry

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The potential function of anti-CD3 scFv-Fc may be to enhance the cytotoxicity of T cells against tumor cells through their activation, resulting in improved anti-tumor effects.

• Alternative Names
• Cluster of differentiation 3; CD3

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
  Phosphorylated also by PKC; leading to the TCR complex down-regulation.
  Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
  Glycosylation at Asn52 and Asn92
  Ubiquitination at Lys32, Lys79, Lys93, Lys95, Lys150, and Lys164
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 2 sites

• Protein Refseq
• XP_005271781.1; XP_006719004.1; XP_054226470.1; NP_000064.1

• Function
• Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.
  When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.
  All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.
  Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

• HPAB-0543-WJ
• Mouse Anti-CD3 Recombinant Antibody (clone YTH 12.5)

• HPAB-0543-WJ-F(E)
• Mouse Anti-CD3 Recombinant Antibody (clone YTH 12.5); Fab Fragment

• HPAB-0543-WJ-S(P)
• Mouse Anti-CD3 Recombinant Antibody (clone YTH 12.5); scFv Fragment

• VS-1024-FY202
• Anti-CD3 (clone YTH 12.5) Recombinant Antibody Coupled Liposome (VS-1024-FY202)

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