Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122); Fab Fragment (CAT#: HPAB-0367-YC-F(E))
The product is a novel CD46 modulator that effectively targets cancer stem cell and may be used to treat patients suffering from a wide variety of malignancies. The data show that SC1.N122 is a pan-CD46 antibody, as it bound to CD46 exons 1-6, CD46D-His, CD46F-His and CD46J-His.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/ihc_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/211_E5_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/211_E5_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/209_E5_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/209_E5_1_blue_red_green.jpg
Figure 5 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16903/38899_A_9_3.jpg
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16903/38899_A_9_3.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
Specifications
- Immunogen
- Both the recombinant fusion protein comprising the extracellular portion of CD46-D-His and two synthetic peptides derived from the CD46 protein sequence and located within the exon-exon junctions of exons 6-8 and 6-9.
- Host Species
- Mouse
- Type
- Mouse Fab
- Specificity
- Human CD46
- Species Reactivity
- Human
- Clone
- SC1.N122
- Applications
- ELISA, FC
- Related Disease
- Hyperproliferative disorder
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD46 Molecule, Complement Regulatory Protein; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; MIC10; MCP; TLX; Trophoblast-Lymphocyte Cross-Reactive Antigen; Complement Membrane Cofactor Protein; Trophoblast Leucocyte Common Antigen; Measles Virus Receptor; CD46 Antigen; TRA2.10; AHUS2
- Gene ID
- 4179
- UniProt ID
- P15529
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone SC1.N122"
See other products for "CD46"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Human Antibody Products
Mouse Antibody Products
Humanized Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
ScFv Antibody Products
Fab Antibody Products
Antibody Magnetic Beads
ScFv-Fc Chimera Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1132z | Mouse Anti-CD46 Recombinant Antibody (clone 12A2) | WB, ELISA, FC, IF, IHC, IP, FuncS | Mouse IgG1, κ |
| MRO-0308-CN | Rabbit Anti-CD46 Recombinant Antibody (clone JB25-49) | WB, IF, IHC | Rabbit IgG |
| MOR-0022-FY | Mouse Anti-CD46 Recombinant Antibody (clone M177) | FC, FuncS, IA, IP, WB | Mouse IgG1 |
| VS-0723-WK258 | Rabbit Anti-CD46 Recombinant Antibody (VS-0723-WK258) | ELISA, FC | Rabbit IgG |
| VS3-XY3298 | Rabbit Anti-CD46 Recombinant Antibody (clone R06-3I6) | WB, IHC-P, ICC, IF | Rabbit IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for HPAB-0367-YC-F(E). Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: FC, Cyt, Stim, PP, Agonist
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
-1.png)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, WB
Application:
Application: WB, Neut, FuncS
Application: ELISA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, Inhib, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
