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  • Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122); Fab Fragment

Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122); Fab Fragment (CAT#: HPAB-0367-YC-F(E))

The product is a novel CD46 modulator that effectively targets cancer stem cell and may be used to treat patients suffering from a wide variety of malignancies. The data show that SC1.N122 is a pan-CD46 antibody, as it bound to CD46 exons 1-6, CD46D-His, CD46F-His and CD46J-His.


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Subcellular Location
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
Figure 2 IHC staining of human placenta
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/ihc_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/211_E5_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/209_E5_1_blue_red_green.jpg
Normal Tissue
Figure 5 Colon
Figure 5 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16903/38899_A_9_3.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
Figure 6 RNA cell line category: Low cell line specificity
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46

Specifications

  • Immunogen
  • Both the recombinant fusion protein comprising the extracellular portion of CD46-D-His and two synthetic peptides derived from the CD46 protein sequence and located within the exon-exon junctions of exons 6-8 and 6-9.
  • Host Species
  • Mouse
  • Type
  • Mouse Fab
  • Specificity
  • Human CD46
  • Species Reactivity
  • Human
  • Clone
  • SC1.N122
  • Applications
  • ELISA, FC
  • Related Disease
  • Hyperproliferative disorder

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • CD46 Molecule, Complement Regulatory Protein; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; MIC10; MCP; TLX; Trophoblast-Lymphocyte Cross-Reactive Antigen; Complement Membrane Cofactor Protein; Trophoblast Leucocyte Common Antigen; Measles Virus Receptor; CD46 Antigen; TRA2.10; AHUS2

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-1132z Mouse Anti-CD46 Recombinant Antibody (clone 12A2) WB, ELISA, FC, IF, IHC, IP, FuncS Mouse IgG1, κ
HPAB-0524-CN Human Anti-CD46 Recombinant Antibody (HPAB-0524-CN) WB, ELISA, FC, IHC, IP Human IgG1
HPAB-0525-CN Human Anti-CD46 Recombinant Antibody (HPAB-0525-CN) WB, ELISA, FC, IHC, IP Human IgG1
HPAB-0367-YC Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122) ELISA, FC Mouse IgG
HPAB-0368-YC Mouse Anti-CD46 Recombinant Antibody (HPAB-0368-YC) ELISA, FC Mouse IgG

Human Antibody

CAT Product Name Application Type
TAB-0288CL Human Anti-CD46 Recombinant Antibody (TAB-0288CL) RIA, ELISA, FC Human IgG1
TAB-0289CL Human Anti-CD46 Recombinant Antibody (TAB-0289CL) RIA, ELISA, FC Human IgG1
TAB-0290CL Human Anti-CD46 Recombinant Antibody (TAB-0290CL) RIA, ELISA, FC Human IgG1
TAB-0291CL Human Anti-CD46 Recombinant Antibody (TAB-0291CL) RIA, ELISA, FC Human IgG1
TAB-267LC-F(E) Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-267LC-F(E)) IHC, ELISA Human Fab

Mouse Antibody

CAT Product Name Application Type
TAB-268LC Mouse Anti-CD46 Recombinant Antibody (TAB-268LC) Cyt, FuncS Mouse IgG
TAB-269LC Mouse Anti-CD46 Recombinant Antibody (TAB-269LC) Cyt, FuncS Mouse IgG
TAB-272LC Anti-Human CD46 Recombinant Antibody (mPA7) FuncS, Inhib, WB
TAB-268LC-S(P) Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-268LC-S(P)) FC, ELISA Mouse scFv
TAB-269LC-S(P) Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-269LC-S(P)) FC, ELISA Mouse scFv

Humanized Antibody

CAT Product Name Application Type
TAB-270LC Human Anti-CD46 Recombinant Antibody (TAB-270LC) Cyt, FuncS Humanized IgG1, κ
TAB-271LC Human Anti-CD46 Recombinant Antibody (TAB-271LC) Cyt, FuncS Humanized IgG1, κ
TAB-270LC-S(P) Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-270LC-S(P)) FC, ELISA Humanized scFv
TAB-271LC-S(P) Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-271LC-S(P)) FC, ELISA Humanized scFv
TAB-270LC-F(E) Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-270LC-F(E)) FC, ELISA Humanized Fab

Blocking Antibody

CAT Product Name Application Type
NEUT-385CQ Mouse Anti-CD46 Recombinant Antibody (clone TRA-2-10) FC, Block, IF, IP Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0564 Hi-Affi™ Rabbit Anti-CD46 Recombinant Antibody (clone DS564AB) ICC, IHC-P, WB Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0524-CN-S(P) Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0524-CN-S(P)) WB, ELISA, FC, IHC, IP Human scFv
HPAB-0525-CN-S(P) Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0525-CN-S(P)) WB, ELISA, FC, IHC, IP Human scFv
HPAB-0366-YC-S(P) Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0366-YC-S(P)) ELISA, FC Humanized scFv
HPAB-0368-YC-S(P) Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0368-YC-S(P)) ELISA, FC Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0524-CN-F(E) Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0524-CN-F(E)) WB, ELISA, FC, IHC, IP Human Fab
HPAB-0525-CN-F(E) Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0525-CN-F(E)) WB, ELISA, FC, IHC, IP Human Fab
HPAB-0368-YC-F(E) Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0368-YC-F(E)) ELISA, FC Mouse Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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