anti-CD5 immunotoxin HB21 (IgG)-PT (CAT#: AGTO-L052T)
This immunotoxin was achieved by conjugating/fusing the Anti-CD5 monoclonal antibody to Pyrularia thionin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to T cells which express the CD5 antigen and the toxin enters cells by receptor-mediated endocytosis. Then PT causes a number of damaging cellular responses including hemolysis of erythrocytes; depolarization of the cellular membrane; activation of a calcium ion channel; and activation of endogenous phospholipase A2 enzyme. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.
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Normal Tissue
RNA Expression
Figure 1 Testis
(Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43416/101306_A_5_6.jpg
(Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43416/101306_A_5_6.jpg
Figure 2 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43416/101306_A_7_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43416/101306_A_7_8.jpg
Figure 3 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43416/101306_A_5_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43416/101306_A_5_8.jpg
Figure 4 RNA cell line category: Group enriched (JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110448-CD5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110448-CD5
Figure 4 RNA cell line category: Group enriched (JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110448-CD5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110448-CD5
Specifications
- Host Species
- Humanized (from Mouse)
- Species Reactivity
- Human
- Clone
- HB21
- Molecule Class
- L kappa; IgG1-PT
- Toxin Description
- PT is a small, highly basic and stable, 47 amino acid residue peptide. PT belongs to a family of peptides which, with the exception of crambin, exhibit some degree of toxicity towards animals and cultured cells including yeast, fungi, bacteria, and mammalian cells. PT, however, does not display any toxicity towards bacteria. At moderate concentrations it is toxic to cancer cells in culture and at higher concentrations it is toxic to mice. PT causes a number of damaging cellular responses including hemolysis of erythrocytes, depolarization of the cellular membrane, activation of a calcium ion channel, and activation of endogenous phospholipase A2 enzyme.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- T cell leukemias or lymphomas, graft- versus-host diseases, and autoimmune diseases
Target
- Alternative Names
- CD5; CD5 molecule; T1; LEU1; T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; T cell leukemias; lymphomas; graft- versus-host diseases; autoimmune diseases; Pyrularia thionin; Pyrularia pubera; thionin; PT
- Gene ID
- 921
- UniProt ID
- P06127
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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