anti-CD5 immunotoxin H65 (scFv)-PT (CAT#: AGTO-L053T)

This immunotoxin was achieved by conjugating/fusing the Anti-CD5 scFv to Pyrularia thionin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to T cells which express the CD5 antigen and the toxin enters cells by receptor-mediated endocytosis. Then PT causes a number of damaging cellular responses including hemolysis of erythrocytes; depolarization of the cellular membrane; activation of a calcium ion channel; and activation of endogenous phospholipase A2 enzyme. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.


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Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • H65
  • Molecule Class
  • scFv-PT
  • Toxin Description
  • PT is a small, highly basic and stable, 47 amino acid residue peptide. PT belongs to a family of peptides which, with the exception of crambin, exhibit some degree of toxicity towards animals and cultured cells including yeast, fungi, bacteria, and mammalian cells. PT, however, does not display any toxicity towards bacteria. At moderate concentrations it is toxic to cancer cells in culture and at higher concentrations it is toxic to mice. PT causes a number of damaging cellular responses including hemolysis of erythrocytes, depolarization of the cellular membrane, activation of a calcium ion channel, and activation of endogenous phospholipase A2 enzyme.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • T cell leukemias or lymphomas, graft- versus-host diseases, and autoimmune diseases

Target

  • Alternative Names
  • CD5; CD5 molecule; T1; LEU1; T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; T cell leukemias; lymphomas; graft- versus-host diseases; autoimmune diseases; Pyrularia thionin; Pyrularia pubera; thionin; PT

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-L052G anti-CD5 immunotoxin HB21 (IgG)-Gel Cytotoxicity assay, Functional assay
AGTO-L052R anti-CD5 immunotoxin HB21 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L052T anti-CD5 immunotoxin HB21 (IgG)-PT Cytotoxicity assay, Functional assay
AGTO-L053G anti-CD5 immunotoxin H65 (scFv)-Gel Cytotoxicity assay, Functional assay
AGTO-L053R anti-CD5 immunotoxin H65 (scFv)-RTA Cytotoxicity assay, Functional assay

Chimeric Antibody

CAT Product Name Application Type
TAB-309LC Anti-Human CD5 Recombinant Antibody (H3L1) FC, SPR Chimeric antibody (mouse/human)
TAB-310LC Anti-Human CD5 Recombinant Antibody WB Chimeric antibody (mouse/human)
TAB-309LC-S(P) Anti-Human CD5 Recombinant Antibody scFv Fragment (H3L1) FC, SPR Chimeric antibody (mouse/human)
TAB-310LC-S(P) Anti-Human CD5 Recombinant Antibody scFv Fragment WB Chimeric antibody (mouse/human)
TAB-309LC-F(E) Anti-Human CD5 Recombinant Antibody Fab Fragment (H3L1) FC, SPR Chimeric antibody (mouse/human)

Blocking Antibody

CAT Product Name Application Type
NEUT-392CQ Rat Anti-CD5 Recombinant Antibody (clone 53-7.3) FC, IHC-Fr, IP, ELISA, Block Rat IgG2a, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0567 Hi-Affi™ Rabbit Anti-CD5 Recombinant Antibody (clone DS567AB) IHC-P Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0779-WJ Human Anti-CD5 Recombinant Antibody (clone 1D8) ELISA, WB Chimeric (mouse/human) IgG
HPAB-0780-WJ Human Anti-CD5 Recombinant Antibody (clone 3I21) ELISA, WB Chimeric (mouse/human) IgG
HPAB-0781-WJ Human Anti-CD5 Recombinant Antibody (clone 4H10) ELISA, WB Chimeric (mouse/human) IgG
HPAB-0782-WJ Human Anti-CD5 Recombinant Antibody (clone 8J23) ELISA, WB Chimeric (mouse/human) IgG
HPAB-0783-WJ Human Anti-CD5 Recombinant Antibody (clone 5O4) ELISA, WB Chimeric (mouse/human) IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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