This immunotoxin was achieved by conjugating/fusing the Anti-CD5 scFv to Pyrularia thionin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to T cells which express the CD5 antigen and the toxin enters cells by receptor-mediated endocytosis. Then PT causes a number of damaging cellular responses including hemolysis of erythrocytes; depolarization of the cellular membrane; activation of a calcium ion channel; and activation of endogenous phospholipase A2 enzyme. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-884 | Mouse Anti-CD5 Recombinant Antibody (clone Zolimomab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | Mouse IgG1 |
TAB-885 | Mouse Anti-CD5 Recombinant Antibody (clone Telimomab); Fab Fragment | FuncS, IF, Neut, ELISA, FC, IP, ICC | Mouse Fab |
TAB-308LC | Anti-Human CD5 Recombinant Antibody (5D7) | Cyt, FC, FuncS | |
TAB-308LC-S(P) | Anti-Human CD5 Recombinant Antibody scFv Fragment (5D7) | FC, SPR | |
TAB-308LC-F(E) | Anti-Human CD5 Recombinant Antibody Fab Fragment (5D7) | FC, SPR |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L052G | anti-CD5 immunotoxin HB21 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
AGTO-L052R | anti-CD5 immunotoxin HB21 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L052T | anti-CD5 immunotoxin HB21 (IgG)-PT | Cytotoxicity assay, Functional assay | |
AGTO-L053G | anti-CD5 immunotoxin H65 (scFv)-Gel | Cytotoxicity assay, Functional assay | |
AGTO-L053R | anti-CD5 immunotoxin H65 (scFv)-RTA | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-309LC | Anti-Human CD5 Recombinant Antibody (H3L1) | FC, SPR | Chimeric antibody (mouse/human) |
TAB-310LC | Anti-Human CD5 Recombinant Antibody | WB | Chimeric antibody (mouse/human) |
TAB-309LC-S(P) | Anti-Human CD5 Recombinant Antibody scFv Fragment (H3L1) | FC, SPR | Chimeric antibody (mouse/human) |
TAB-310LC-S(P) | Anti-Human CD5 Recombinant Antibody scFv Fragment | WB | Chimeric antibody (mouse/human) |
TAB-309LC-F(E) | Anti-Human CD5 Recombinant Antibody Fab Fragment (H3L1) | FC, SPR | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-392CQ | Rat Anti-CD5 Recombinant Antibody (clone 53-7.3) | FC, IHC-Fr, IP, ELISA, Block | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0567 | Hi-Affi™ Rabbit Anti-CD5 Recombinant Antibody (clone DS567AB) | IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0779-WJ | Human Anti-CD5 Recombinant Antibody (clone 1D8) | ELISA, WB | Chimeric (mouse/human) IgG |
HPAB-0780-WJ | Human Anti-CD5 Recombinant Antibody (clone 3I21) | ELISA, WB | Chimeric (mouse/human) IgG |
HPAB-0781-WJ | Human Anti-CD5 Recombinant Antibody (clone 4H10) | ELISA, WB | Chimeric (mouse/human) IgG |
HPAB-0782-WJ | Human Anti-CD5 Recombinant Antibody (clone 8J23) | ELISA, WB | Chimeric (mouse/human) IgG |
HPAB-0783-WJ | Human Anti-CD5 Recombinant Antibody (clone 5O4) | ELISA, WB | Chimeric (mouse/human) IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0779-WJ-S(P) | Mouse Anti-CD5 Recombinant Antibody (clone 1D8); scFv Fragment | ELISA, WB | Mouse scFv |
HPAB-0780-WJ-S(P) | Mouse Anti-CD5 Recombinant Antibody (clone 3I21); scFv Fragment | ELISA, WB | Mouse scFv |
HPAB-0781-WJ-S(P) | Mouse Anti-CD5 Recombinant Antibody (clone 4H10); scFv Fragment | ELISA, WB | Mouse scFv |
HPAB-0782-WJ-S(P) | Mouse Anti-CD5 Recombinant Antibody (clone 8J23); scFv Fragment | ELISA, WB | Mouse scFv |
HPAB-0783-WJ-S(P) | Mouse Anti-CD5 Recombinant Antibody (clone 5O4); scFv Fragment | ELISA, WB | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0779-WJ-F(E) | Human Anti-CD5 Recombinant Antibody (clone 1D8); Fab Fragment | ELISA, WB | Chimeric (mouse/human) Fab |
HPAB-0780-WJ-F(E) | Human Anti-CD5 Recombinant Antibody (clone 3I21); Fab Fragment | ELISA, WB | Chimeric (mouse/human) Fab |
HPAB-0781-WJ-F(E) | Human Anti-CD5 Recombinant Antibody (clone 4H10); Fab Fragment | ELISA, WB | Chimeric (mouse/human) Fab |
HPAB-0782-WJ-F(E) | Human Anti-CD5 Recombinant Antibody (clone 8J23); Fab Fragment | ELISA, WB | Chimeric (mouse/human) Fab |
HPAB-0783-WJ-F(E) | Human Anti-CD5 Recombinant Antibody (clone 5O4); Fab Fragment | ELISA, WB | Chimeric (mouse/human) Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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