anti-CD5 immunotoxin H65 (scFv)-Gel (AGTO-L053G)
This immunotoxin was achieved by conjugating/fusing the Anti-CD5 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to T cells which express the CD5 antigen. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.
Specifications
- Host
- Mouse
- Species Reactivity
- Human
- Clone
- H65
- Molecule Class
- scFv-Gel
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- T cell leukemias or lymphomas, graft- versus-host diseases, and autoimmune diseases
Target
- Alternative Names
- CD5; CD5 molecule; T1; LEU1; T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; T cell leukemias
- Entrez Gene ID
- 921
- UniProt ID
- P06127
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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