This immunotoxin was achieved by conjugating/fusing the Anti-CD7 monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating acute lymphoblastic leukemia (ALL).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-183-F(E) | Recombinant Anti-human CD7 Antibody Fab Fragment | IP, Neut, FuncS | Fab |
MHH-183-F(E) | Recombinant Human Anti-human CD7 Antibody Fab Fragment | Neut, WB, FuncS | Fab |
FAMAB-0049CQ-F(E) | Human Anti-CD7 Recombinant Antibody (clone CHT2); Fab Fragment | IHC, FC, Block, IF | Chimeric (mouse/human) Fab |
FAMAB-0050CQ-F(E) | Mouse Anti-CD7 Recombinant Antibody (clone RFT2); Fab Fragment | IHC, FC, Block, IF | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-183-S(P) | Recombinant Anti-human CD7 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
MHH-183-S(P) | Recombinant Human Anti-human CD7 Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
FAMAB-0049CQ-S(P) | Mouse Anti-CD7 Recombinant Antibody (clone CHT2); scFv Fragment | IHC, FC, Block, IF | Mouse scFv |
FAMAB-0050CQ-S(P) | Mouse Anti-CD7 Recombinant Antibody (clone RFT2); scFv Fragment | IHC, FC, Block, IF | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G011E | Anti-CD7 immunotoxin TH-69 (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G011R | Anti-CD7 immunotoxin TH-69 (scFv)-RTA | Cytotoxicity assay, Function study | |
AGTO-G011S | Anti-CD7 immunotoxin TH-69 (scFv)-Sap | Cytotoxicity assay, Function study | |
AGTO-G082R | Anti-CD7 immunotoxin 3A1e (IgG)-RTA | Cytotoxicity assay, Function study | |
AGTO-G082S | Anti-CD7 immunotoxin 3A1e (IgG)-Sap | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-001LC-VHH | Anti-Human CD7 Recombinant Antibody | IF, ELISA | Single domain antibody |
HPAB-0265-YJ-VHH | Recombinant Camel Anti-CD7 Single Domain Antibody (VHH-6) | ELISA, FC, IF | Camel VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0577 | Hi-Affi™ Rabbit Anti-CD7 Recombinant Antibody (clone DS577AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-1078CQ | Human Anti-CD7 Recombinant Antibody (clone YTH3.2.6) | ELISA, FC, IF, IHC | Human IgG1 |
VS3-XY399 | Mouse Anti-CD7 Recombinant Antibody (clone 4F9) | ELISA, WB, IHC, FC | Mouse IgG1 |
VS3-XY400 | Mouse Anti-CD7 Recombinant Antibody (clone 8E12) | ELISA, WB, IHC, FC | Mouse IgG1 |
VS3-XY401 | Mouse Anti-CD7 Recombinant Antibody (clone 4AUCHT2) | FC, IF | Mouse IgG1 |
VS3-WK1243 | Mouse Anti-CD7 Recombinant Antibody (VS3-WK1243) | WB | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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