Anti-CD7 immunotoxin (IgG)-PE

CAT#: AGTO-G082E

This immunotoxin was achieved by conjugating/fusing the Anti-CD7 monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating acute lymphoblastic leukemia (ALL).

Gene Expression
Figure 1 Colon Figure 2 Spleen Figure 3 RNA cell line category: Cell line enhanced (Hep G2, JURKAT, MOLT-4)

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Molecule Class
  • L kappa; IgG-PE
  • Toxin Description
  • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Acute lymphoblastic leukemia (ALL)

Target

  • Alternative Names
  • CD7; CD7 molecule; GP40; TP41; Tp40; LEU-9; T-cell antigen CD7; p41 protein; CD7 antigen (p41); T-cell leukemia antigen; T-cell surface antigen Leu-9; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE106
REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
Inquiry
Navs

Customer Review

Submit a review or a question

There are currently no Customer reviews or questions for AGTO-G082E. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Article title:
DOI/PubMed URL:
Email:
Name:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "CD7"

Select a product category from the dropdown menu below to view related products.

CAT Product Name Application Type
AGTO-G011E Anti-CD7 immunotoxin TH-69 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G011R Anti-CD7 immunotoxin TH-69 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G011S Anti-CD7 immunotoxin TH-69 (scFv)-Sap Cytotoxicity assay, Function study
AGTO-G082R Anti-CD7 immunotoxin (IgG)-RTA Cytotoxicity assay, Function study
AGTO-G082S Anti-CD7 immunotoxin (IgG)-Sap Cytotoxicity assay, Function study
CAT Product Name Application Type
TAB-001LC-VHH Anti-Human CD7 Recombinant Antibody IF, ELISA Single domain antibody
HPAB-0265-YJ-VHH Recombinant Camel Anti-CD7 Single Domain Antibody (HPAB-0265-YJ-VHH) ELISA, FC, IF Camel VHH
CAT Product Name Application Type
MOR-0577 Hi-Affi™ Rabbit Anti-CD7 Recombinant Antibody (clone DS577AB) ICC, IHC-P, IP, WB Rabbit IgG
CAT Product Name Application Type
VS-0724-YC714 AbPlus™ Anti-CD7 Magnetic Beads (VS-0724-YC714) IP, Protein Purification
CAT Product Name Application Type
VS-0225-XY68 CytoStream™ Mouse Anti-CD7 Recombinant Antibody (VS-0225-XY68) FC Mouse IgG2a, kappa
CAT Product Name Application Type
VS-0325-FY126 Human Anti-CD7 scFv-Fc Chimera (VS-0325-FY126) ADCC Human IgG1, scFv-Fc
CAT Product Name Application Type
VS-0425-YC728 Recombinant Anti-CD7 Vesicular Antibody, EV Displayed (VS-0425-YC728) ELISA, FC, Cell-uptake
Specific Inquiry
Go to compare Add to compare

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Go to compare

Go to compare