Anti-CD7 immunotoxin 3A1e (IgG)-PE (CAT#: AGTO-G082E)

This immunotoxin was achieved by conjugating/fusing the Anti-CD7 monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating acute lymphoblastic leukemia (ALL).


Specific Inquiry
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  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • 3A1e
  • Molecule Class
  • L kappa; IgG-PE
  • Toxin Description
  • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Acute lymphoblastic leukemia (ALL)

Target

  • Alternative Names
  • CD7; CD7 molecule; GP40; TP41; Tp40; LEU-9; T-cell antigen CD7; p41 protein; CD7 antigen (p41); T-cell leukemia antigen; T-cell surface antigen Leu-9; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE106

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-G011E Anti-CD7 immunotoxin TH-69 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G011R Anti-CD7 immunotoxin TH-69 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G011S Anti-CD7 immunotoxin TH-69 (scFv)-Sap Cytotoxicity assay, Function study
AGTO-G082R Anti-CD7 immunotoxin 3A1e (IgG)-RTA Cytotoxicity assay, Function study
AGTO-G082S Anti-CD7 immunotoxin 3A1e (IgG)-Sap Cytotoxicity assay, Function study

Single-domain Antibody

CAT Product Name Application Type
TAB-001LC-VHH Anti-Human CD7 Recombinant Antibody IF, ELISA Single domain antibody
HPAB-0265-YJ-VHH Recombinant Camel Anti-CD7 Single Domain Antibody (VHH-6) ELISA, FC, IF Camel VHH

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0577 Hi-Affi™ Rabbit Anti-CD7 Recombinant Antibody (clone DS577AB) ICC, IHC-P, IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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