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Anti-CD7 immunotoxin TH-69 (scFv)-RTA (AGTO-G011R)

This immunotoxin was achieved by conjugating/fusing the Anti-CD7 scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human CD7, a surface antigen of leukemic T cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of acute Leukemic T Cells.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
TH-69
Molecule Class
scFv-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Acute Leukemic T Cells
Target
Alternative Names
CD7; CD7 molecule; GP40; TP41; Tp40; LEU-9; T-cell antigen CD7; p41 protein
Entrez Gene ID
924
UniProt ID
P09564

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

See other products for "CD7"
Anti-CD7 immunotoxin 3A1e (IgG)-PE    ( AGTO-G082E )
Recombinant Mouse Anti-CD7 Antibody Fab Fragment (RFT2)    ( FAMAB-0050CQ-F(E) )
Recombinant Human Anti-human CD7 Antibody Fab Fragment    ( MHH-183-F(E) )
Recombinant Anti-human CD7 Antibody Fab Fragment    ( MOB-183-F(E) )
Recombinant Anti-human CD7 Antibody    ( MOB-183 )
Anti-CD7 immunotoxin TH-69 (scFv)-PE    ( AGTO-G011E )
Recombinant Mouse Anti-Human CD7 Molecule Antibody (clone DBC.38)    ( MOB-0274MZ )
Recombinant Human Anti-CD7 Antibody (CHT2)    ( FAMAB-0049CQ )
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