Anti-CD7 immunotoxin TH-69 (scFv)-RTA (CAT#: AGTO-G011R)

This immunotoxin was achieved by conjugating/fusing the Anti-CD7 scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human CD7, a surface antigen of leukemic T cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of acute Leukemic T Cells.


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  • Datasheet
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Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • TH-69
  • Molecule Class
  • scFv-RTA
  • Toxin Description
  • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Acute Leukemic T Cells

Target

  • Alternative Names
  • CD7; CD7 molecule; GP40; TP41; Tp40; LEU-9; T-cell antigen CD7; p41 protein; CD7 antigen (p41); T-cell leukemia antigen; T-cell surface antigen Leu-9; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone TH-69"

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Recombinant Antibody

Immunotoxin

CAT Product Name Application Type
AGTO-G011E Anti-CD7 immunotoxin TH-69 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G011S Anti-CD7 immunotoxin TH-69 (scFv)-Sap Cytotoxicity assay, Function study
AGTO-G082E Anti-CD7 immunotoxin 3A1e (IgG)-PE Cytotoxicity assay, Function study
AGTO-G082R Anti-CD7 immunotoxin 3A1e (IgG)-RTA Cytotoxicity assay, Function study
AGTO-G082S Anti-CD7 immunotoxin 3A1e (IgG)-Sap Cytotoxicity assay, Function study

Single-domain Antibody

CAT Product Name Application Type
TAB-001LC-VHH Anti-Human CD7 Recombinant Antibody IF, ELISA Single domain antibody
HPAB-0265-YJ-VHH Recombinant Camel Anti-CD7 Single Domain Antibody (VHH-6) ELISA, FC, IF Camel VHH

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0577 Hi-Affi™ Rabbit Anti-CD7 Recombinant Antibody (clone DS577AB) ICC, IHC-P, IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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