Anti-CD7 immunotoxin (IgG)-RTA
CAT#: AGTO-G082R
This immunotoxin was achieved by conjugating/fusing the Anti-CD7 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of acute lymphoblastic leukemia (ALL).
Gene Expression
Normal Tissue
Figure 1 Colon
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39079/133943_A_8_3.jpg
Normal Tissue
Figure 2 Spleen
Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39079/133943_B_7_4.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Hep G2, JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000173762-CD7
❮
❯
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- L kappa; IgG-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Acute lymphoblastic leukemia (ALL)
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for AGTO-G082R. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CD7"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-183-F(E) | Recombinant Anti-human CD7 Antibody Fab Fragment | IP, Neut, FuncS | Fab |
| MHH-183-F(E) | Recombinant Human Anti-human CD7 Antibody Fab Fragment | Neut, WB, FuncS | Fab |
| FAMAB-0049CQ-F(E) | Human Anti-CD7 Recombinant Antibody (clone CHT2); Fab Fragment | IHC, FC, Block, IF | Chimeric (mouse/human) Fab |
| FAMAB-0050CQ-F(E) | Mouse Anti-CD7 Recombinant Antibody (clone RFT2); Fab Fragment | IHC, FC, Block, IF | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-183-S(P) | Recombinant Anti-human CD7 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| MHH-183-S(P) | Recombinant Human Anti-human CD7 Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| FAMAB-0049CQ-S(P) | Mouse Anti-CD7 Recombinant Antibody (clone CHT2); scFv Fragment | IHC, FC, Block, IF | Mouse scFv |
| FAMAB-0050CQ-S(P) | Mouse Anti-CD7 Recombinant Antibody (clone RFT2); scFv Fragment | IHC, FC, Block, IF | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G011E | Anti-CD7 immunotoxin TH-69 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G011R | Anti-CD7 immunotoxin TH-69 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G011S | Anti-CD7 immunotoxin TH-69 (scFv)-Sap | Cytotoxicity assay, Function study | |
| AGTO-G082E | Anti-CD7 immunotoxin (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-G082S | Anti-CD7 immunotoxin (IgG)-Sap | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-001LC-VHH | Anti-Human CD7 Recombinant Antibody | IF, ELISA | Single domain antibody |
| HPAB-0265-YJ-VHH | Recombinant Camel Anti-CD7 Single Domain Antibody (HPAB-0265-YJ-VHH) | ELISA, FC, IF | Camel VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0577 | Hi-Affi™ Rabbit Anti-CD7 Recombinant Antibody (clone DS577AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0049CQ | Human Anti-CD7 Recombinant Antibody (clone CHT2) | IHC, FC, Block, IF | Chimeric (mouse/human) IgG1, κ |
| FAMAB-0050CQ | Mouse Anti-CD7 Recombinant Antibody (clone RFT2) | IHC, FC, Block, IF | Mouse IgG1, κ |
| ZG-0315U | Rabbit Anti-CD7 Recombinant Antibody (clone C21-Q) | IHC-P | Rabbit IgG |
| VS3-FY1677 | Rabbit Anti-CD7 Recombinant Antibody (clone R03-8G3) | WB, IHC-Fr, IHC-P, IF, IP | Rabbit IgG |
| VS11-QX43 | Mouse Anti-CD7 Recombinant Antibody (clone 3A1f) | FC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC714 | AbPlus™ Anti-CD7 Magnetic Beads (VS-0724-YC714) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY68 | CytoStream™ Mouse Anti-CD7 Recombinant Antibody (VS-0225-XY68) | FC | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY126 | Human Anti-CD7 scFv-Fc Chimera (VS-0325-FY126) | ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY372 | Anti-CD7 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1214 | Anti-Human CD7 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC728 | Recombinant Anti-CD7 Vesicular Antibody, EV Displayed (VS-0425-YC728) | ELISA, FC, Cell-uptake |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: WB, Neut, FuncS
Application: WB, ELISA, FuncS
Application: IHC, ELISA, FC, WB, ADCC, FuncS
Application: FC, IB, Block, Inhib, FuncS, ELISA, FACS, IP, IF
Application: FC, IHC-Fr, IP, ELISA, Block
Application: WB, ELISA, IHC, IP, SPR, FuncS
Application: Neut, IHC, Activ, FuncS, IF, ELISA
Application: Inhib, FC, WB
Application: ELISA, Inhib, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
