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Anti-CD7 immunotoxin TH-69 (scFv)-Sap (AGTO-G011S)

This immunotoxin was achieved by conjugating/fusing the Anti-CD7 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human CD7, a surface antigen of leukemic T cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of acute Leukemic T Cells.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
TH-69
Molecule Class
scFv-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Acute Leukemic T Cells
Target
Alternative Names
CD7; CD7 molecule; GP40; TP41; Tp40; LEU-9; T-cell antigen CD7; p41 protein
Entrez Gene ID
924
UniProt ID
P09564

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Recombinant Human Anti-human CD7 Antibody    ( MHH-183 )
Anti-CD7 Antibody-Cytokine Fusion Protein, scFv (scFv3A1F)-sFasL    ( ACFP-SH121 )
Hi-Affi™ Recombinant Rabbit Anti-CD7 Monoclonal Antibody (DS577AB)    ( MOR-0577 )
Anti-CD7 immunotoxin 3A1e (IgG)-PE    ( AGTO-G082E )
Recombinant Anti-human CD7 Antibody scFv Fragment    ( MOB-183-S(P) )
Recombinant Human Anti-human CD7 Antibody scFv Fragment    ( MHH-183-S(P) )
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