Anti-CD7 immunotoxin TH-69 (scFv)-Sap

CAT#: AGTO-G011S

This immunotoxin was achieved by conjugating/fusing the Anti-CD7 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human CD7, a surface antigen of leukemic T cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of acute Leukemic T Cells.

Gene Expression
Figure 1 Colon Figure 2 Spleen Figure 3 RNA cell line category: Cell line enhanced (Hep G2, JURKAT, MOLT-4)

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • TH-69
  • Molecule Class
  • scFv-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Acute Leukemic T Cells

Target

  • Alternative Names
  • CD7; CD7 molecule; GP40; TP41; Tp40; LEU-9; T-cell antigen CD7; p41 protein; CD7 antigen (p41); T-cell leukemia antigen; T-cell surface antigen Leu-9; saporin; saporin-6; saporin-S8; SAP
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Effective at Various pHs
Tested stability at different pH levels and found it remained active and specific across a range.
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User-Friendly Aliquoting
Aliquotting was easy, and the smaller aliquots maintained stability for a long duration without degradation.
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Appropriate for Light-Sensitive Applications
Wrapped in foil, this antibody worked well in light-sensitive experiments with no indications of degradation.

Q&As

  1. How can I prevent antibody aggregation?

    A: Use stabilizers such as glycerol or BSA, store at specified temperatures, and refrain from doing repeated freeze-thaw cycles.

  2. Can the antibody be labeled with a luminous dye?

    A: Yes, however in order to prevent interference from unreacted dye, follow the correct conjugation techniques and purify the labeled antibody.

  3. How should I set up a control for my experiment?

    A: Add relevant positive and negative controls, such as known positive samples and isotype controls.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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