Anti-CD7 immunotoxin TH-69 (scFv)-Sap (CAT#: AGTO-G011S)

This immunotoxin was achieved by conjugating/fusing the Anti-CD7 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human CD7, a surface antigen of leukemic T cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of acute Leukemic T Cells.


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Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • TH-69
  • Molecule Class
  • scFv-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Acute Leukemic T Cells

Target

  • Alternative Names
  • CD7; CD7 molecule; GP40; TP41; Tp40; LEU-9; T-cell antigen CD7; p41 protein; CD7 antigen (p41); T-cell leukemia antigen; T-cell surface antigen Leu-9; saporin; saporin-6; saporin-S8; SAP

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-G011E Anti-CD7 immunotoxin TH-69 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G011R Anti-CD7 immunotoxin TH-69 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G082E Anti-CD7 immunotoxin 3A1e (IgG)-PE Cytotoxicity assay, Function study
AGTO-G082R Anti-CD7 immunotoxin 3A1e (IgG)-RTA Cytotoxicity assay, Function study
AGTO-G082S Anti-CD7 immunotoxin 3A1e (IgG)-Sap Cytotoxicity assay, Function study

Single-domain Antibody

CAT Product Name Application Type
TAB-001LC-VHH Anti-Human CD7 Recombinant Antibody IF, ELISA Single domain antibody
HPAB-0265-YJ-VHH Recombinant Camel Anti-CD7 Single Domain Antibody (VHH-6) ELISA, FC, IF Camel VHH

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0577 Hi-Affi™ Rabbit Anti-CD7 Recombinant Antibody (clone DS577AB) ICC, IHC-P, IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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