Anti-CD7 immunotoxin TH-69 (scFv)-Sap (CAT#: AGTO-G011S)
This immunotoxin was achieved by conjugating/fusing the Anti-CD7 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human CD7, a surface antigen of leukemic T cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of acute Leukemic T Cells.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Colon
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39079/133943_A_8_3.jpg
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39079/133943_A_8_3.jpg
Figure 2 Spleen
(Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39079/133943_B_7_4.jpg
(Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39079/133943_B_7_4.jpg
Figure 3 RNA cell line category: Cell line enhanced (Hep G2, JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000173762-CD7
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000173762-CD7
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- TH-69
- Molecule Class
- scFv-Sap
- Toxin Description
- Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Acute Leukemic T Cells
Target
- Alternative Names
- CD7; CD7 molecule; GP40; TP41; Tp40; LEU-9; T-cell antigen CD7; p41 protein; CD7 antigen (p41); T-cell leukemia antigen; T-cell surface antigen Leu-9; saporin; saporin-6; saporin-S8; SAP
- Gene ID
- 924
- UniProt ID
- P09564
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| VS3-FY1677 | Rabbit Anti-CD7 Recombinant Antibody (clone R03-8G3) | WB, IHC-Fr, IHC-P, IF, IP | Rabbit IgG |
Customer Reviews and Q&As
Customer Review
Q&As
Effective at Various pHs
Tested stability at different pH levels and found it remained active and specific across a range.
User-Friendly Aliquoting
Aliquotting was easy, and the smaller aliquots maintained stability for a long duration without degradation.
Appropriate for Light-Sensitive Applications
Wrapped in foil, this antibody worked well in light-sensitive experiments with no indications of degradation.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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