Anti-Human CXCR2 Therapeutic Antibody (2B2) (CAT#: TAB-002MZ-VHH)

This antibody specifically binding to chemokine receptor CXCR2 may be used for treatment of diseases involving aberrant functioning of CXCR2.

  • Published Data
  • Datasheet
  • MSDS
  • COA
Inhib

Figure 1 Inhibition of FLAG-tagged nanobody binding to CHO-CXCR2 cells by monovalent nanobodies using FLAG-tagged 163E3 and using FLAG-tagged 127D1.

Competition experiments using a representative FLAGtagged monovalent nanobody from each class (127D1 for class 1 and 163E3 for class 2) showed that nanobodies within the same class compete with each other, whereas nanobodies from different classes do not compete with each other.

Bradley, M. E., Dombrecht, B., Manini, J., Willis, J., Vlerick, D., De Taeye, S., ... & Laeremans, T. (2015). Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action. Molecular pharmacology, 87(2), 251-262.


Specifications

  • Host Species
  • Human
  • Type
  • Single domain antibody
  • Specificity
  • Human
  • Clone
  • 2B2
  • Applications
  • FC, Inhib
  • Related Disease
  • Chronic obstructive pulmonary disease (COPD)

Applications

  • Application Notes
  • The antibody was validated for Inhibition. For details, refer to Published Data.

Target

  • Alternative Names
  • CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

See other products for "CXCR2"

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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