Recombinant Human Antibody (UCA) is capable of binding to H1N1 HA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-H1N1 HA mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-H1N1 HA proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The UCA antibody binds too weakly for cocrystallization with HA head.
Figure 2 Summary of analysis of surface plasmon resonance of Fab binding to immobilized HA (A/Solomon Islands/03/2006) head
Schmidt, A. G., Xu, H., Khan, A. R., O’Donnell, T., Khurana, S., King, L. R., ... & Settembre, E. C. (2013). Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proceedings of the National Academy of Sciences, 110(1), 264-269.
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