Recombinant Human Anti-H2N2 HA Antibody (2G1 ) (CAT#: PABL-487)
Recombinant Human Antibody (2G1 ) is capable of binding to H2N2 HA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-H2N2 HA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-H2N2 HA proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
FuncS
Figure 1 Therapeutic efficacy of MAbs against disease caused by the A/Albany/6/1958 H2N2 virus in mice.
Mice were inoculated on day 0 and treated on day1 with the indicated antibody (8F8, 8M2, 2G1, or a human IgG control) anddose. In each group, six mice were monitored for survival. At the 2G1 200-μg dose (P<0.01), and the 2G1 20-μg dose (P<0.01), treatment conferred a survival advantage by log rank test.
Krause, J. C., Tsibane, T., Tumpey, T. M., Huffman, C. J., Albrecht, R., Blum, D. L., ... & Basler, C. F. (2012). Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses. Journal of virology, 86(11), 6334-6340.
Specifications
- Immunogen
- H2N2 IAV haemagglutinin
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native H2N2 HA
- Species Reactivity
- H2N2 IAV
- Clone
- 2G1
- Applications
- FuncS
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Function Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-203 | Recombinant Human Anti-IAV HA Antibody (3.1) | WB, ELISA, FuncS | IgG |
| PABL-204 | Recombinant Human Anti-IAV HA Antibody (39.29) | Neut, FuncS | IgG |
| PABL-205 | Recombinant Human Anti-IAV HA Antibody (1957) | WB, Neut, FuncS | IgG |
| PABL-206 | Recombinant Human Anti-IAV HA Antibody (1F1) | WB, ELISA, FuncS | IgG |
| PABL-207 | Recombinant Human Anti-IAV HA Antibody (5J8) | FuncS | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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