Afuco™ Anti-IL1R1 Recombinant Antibody (AFC-392CL), ADCC Enhanced
CAT#: AFC-392CL
Anti-IL1R1 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. It is a fully human, immunoglobulin subclass G2 (IgG2) monoclonal antibody that binds the human interleukin-1 (IL-1) receptor type 1, inhibiting the activity of IL-1a and IL-1b.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line ASC TERT1
Immunofluorescent staining of human cell line ASC TERT1 shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1237/1774_H4_18_cr5952945990756_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7779/211_A1_3_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows strong luminal membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29560/ihc_selected.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5823/130948_A_6_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5823/130948_A_8_8.jpg
Normal Tissue
Figure 6 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5823/130948_B_8_5.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5823/130948_A_8_3.jpg
Normal Tissue
Figure 8 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5823/130948_A_9_4.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HHSteC, HSkMC)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115594-IL1R1
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG1
- Species Reactivity
- Human
- Applications
- ELISA, WB
- Related Disease
- Rheumatoid Arthritis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- IL1R1; interleukin 1 receptor, type I; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha; interleukin-1 receptor type 1; IL-1R-1; IL-1RT1; IL-1RT-1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I
- Gene ID
- 3554
- UniProt ID
- P14778
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Related Diseases
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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| NEUT-1293CQ | Hamster Anti-Il1r1 Recombinant Antibody (clone JAMA147) | Neut | Hamster IgG |
| NEUT-1294CQ | Rat Anti-Il1r1 Recombinant Antibody (clone CBL936) | ELISA, IP, Neut, WB | Rat IgG1 |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-1862-FY-F(E) | Human Anti-IL1R1 Recombinant Antibody (clone 26F5); scFv Fragment | ELISA | Human scFv |
| HPAB-1863-FY-F(E) | Human Anti-IL1R1 Recombinant Antibody (clone 15C4); scFv Fragment | ELISA | Human scFv |
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| CAT | Product Name | Application | Type |
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| HPAB-1862-FY-S(P) | Human Anti-IL1R1 Recombinant Antibody (clone 26F5); Fab Fragment | ELISA | Human Fab |
| HPAB-1863-FY-S(P) | Human Anti-IL1R1 Recombinant Antibody (clone 15C4); Fab Fragment | ELISA | Human Fab |
| HPAB-1864-FY-S(P) | Human Anti-IL1R1 Recombinant Antibody (clone 27F2); Fab Fragment | ELISA | Human Fab |
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| VS-0125-FY73 | Human Anti-IL1R1 (clone 26F5) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
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