anti-IL1R1 immunotoxin TP3 (IgG)-PAP

CAT#: AGTO-L026P

This immunotoxin was achieved by conjugating/fusing the Anti-IL1R1 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to osteosarcoma cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of osteosarcoma.

Gene Expression
Figure 1 IF staining of human cell line ASC TERT1 Figure 2 IF staining of human cell line U-2 OS Figure 3 IHC staining of human small intestine Figure 4 Testis Figure 5 Lymph node Figure 6 Cerebral cortex Figure 7 Colon Figure 8 Liver Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HHSteC, HSkMC)

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • TP3
  • Molecule Class
  • IgG-PAP
  • Toxin Description
  • Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Osteosarcoma

Target

  • Alternative Names
  • IL1R1; interleukin 1 receptor, type I; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha; interleukin-1 receptor type 1; IL-1R-1; IL-1RT1; IL-1RT-1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I; Osteosarcoma; Pokeweed Antiviral Protein; Pokeweed; PAP
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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