anti-IL1R1 immunotoxin TP3 (IgG)-PAP (CAT#: AGTO-L026P)

This immunotoxin was achieved by conjugating/fusing the Anti-IL1R1 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to osteosarcoma cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of osteosarcoma.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • TP3
  • Molecule Class
  • IgG-PAP
  • Toxin Description
  • Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Osteosarcoma

Target

  • Alternative Names
  • IL1R1; interleukin 1 receptor, type I; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha; interleukin-1 receptor type 1; IL-1R-1; IL-1RT1; IL-1RT-1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I; Osteosarcoma; Pokeweed Antiviral Protein; Pokeweed; PAP

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "IL1R1"

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-392CL Afuco™ Anti-IL1R1 Recombinant Antibody (AFC-392CL), ADCC Enhanced ELISA, WB Human IgG1

Neutralizing Antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1799 Rabbit Anti-IL1R1 Recombinant Antibody (clone DS1799AB) WB, FC, IP Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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