Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
  • Home
  • INSR
  • Afuco™ Anti-Human INSR ADCC Recombinant Antibody (AGT-182), ADCC Enhanced

Afuco™ Anti-Human INSR ADCC Recombinant Antibody (AGT-182), ADCC Enhanced (CAT#: AFC-423CL)

Anti-INSR ADCC Enhanced Antibody (AGT-182) is an ADCC enhanced antibody produced by our Afuco™ platform. AGT‑182 is an investigational enzyme replacement therapy (ERT) for the treatment of neurological complications in patients with Hunter syndrome. Currently approved treatments for Hunter syndrome do not penetrate the BBB and therefore do not address the severe and progressive neurological complications of the disease. AGT-182 is a fusion protein of iduronate-2-sulfatase (IDS), engineered to cross the BBB by binding to insulin receptors located on the BBB. AGT‑182 crosses the BBB safely at unprecedented levels.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Formats:
  • Isotype Switching:
  • Fc Engineering:
  • Modalities:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/737_C10_2_selected.jpg
Figure 2 IHC staining of human liver
Figure 2 IHC staining of human liver
(Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/ihc_selected.jpg
Figure 3 IF staining of human cell line A-431
Figure 3 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/836_E10_2_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Figure 4 Colon
(landular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_9_3.jpg
Figure 5 Liver
Figure 5 Liver
(Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_4.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_7_5.jpg
Figure 7 Testis
Figure 7 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_6_6.jpg
Figure 8 Skeletal muscle
Figure 8 Skeletal muscle
(Myocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_B_3_6.jpg
Figure 9 Lymph node
Figure 9 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)
Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR
Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)
Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR

Specifications

  • Host Species
  • Human
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Related Disease
  • Hunter Syndrome

Product Property

  • Purity
  • >95% as determined by analysis by SDS-PAGE
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Target

  • Alternative Names
  • INSR; insulin receptor; HHF5; CD220; IR

Related Resources

  • Related Signaling Pathways
  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "INSR"

Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products Rat Antibody Products ScFv Antibody Products Fab Antibody Products Human Antibody Products Mouse Antibody Products MHC Tetramer Products for Cancer Blocking Antibody Products Neutralizing Antibody Products Rabbit Monoclonal Antibody Products Antibody Magnetic Beads Flow Cytometry (FC) related Products ScFv-Fc Chimera Products
CAT Product Name Application Type
MOB-1236z Mouse Anti-INSR Recombinant Antibody (clone 25F8) ELISA, FC, ICC, IF, IHC, FuncS Mouse IgG1, κ
MOB-0984CT Recombinant Mouse anti-Human INSR Monoclonal antibody (94-8) ELISA, FC, IHC-P, IP
HPAB-0129-YC Mouse Anti-INSR Recombinant Antibody (HPAB-0129-YC) ELISA, FC Mouse IgG
HPAB-2351LY Human Anti-INSR Recombinant Antibody (HPAB-2351LY) ELISA, WB, FC, FuncS Humanized IgG
HPAB-2352LY Human Anti-INSR Recombinant Antibody (HPAB-2352LY) ELISA, WB, FC, FuncS Humanized IgG

Customer Reviews and Q&As

Submit a review or a question

There are currently no Customer reviews or questions for AFC-423CL. Click the button above to contact us or submit your feedback about this product.

Popular products with customers

Figure 1 Anti-Human CTLA4 Antibody (TAB-206) in SDS-PAGE

Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) (CAT# TAB-206)
Application: WB, IF, IP, Neut, FuncS, ELISA, FC

Figure 1 Anti-Human IL6 Recombinant Antibody (TAB-253) in ELISA

Anti-Human IL-6 Recombinant Antibody (Olokizumab) (CAT# TAB-253)
Application: WB, ELISA, FC, IP, FuncS, IF, Neut

Figure 1 Anti-S. Aureus Recombinant Antibody (TAB-029) in SDS-PAGE

Anti-S. Aureus Recombinant Antibody (TAB-029) (CAT# TAB-029)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Figure 1 Anti-Human Integrin alpha 5 beta 1 Recombinant Antibody in SDS-PAGE analysis.

Anti-Human Integrin alpha 5 beta 1 Recombinant Antibody (Volociximab) (CAT# TAB-077)
Application: ELISA, IHC

Figure 1 Anti-Human ERBB3 Recombinant Antibody (TAB-H47) in SDS-PAGE

Humanized Anti-Human ERBB3 Recombinant Antibody (TAB-H47) (CAT# TAB-H47)
Application: ELISA, Inhib

Figure 1 Anti-EGFR Recombinant Antibody (TAB-753) in SDS-PAGE

Anti-EGFR Recombinant Antibody (Imgatuzumab) (CAT# TAB-753)
Application: Neut, ELISA, IF, IP, FuncS, FC, WB

Figure 1 Anti-CD40 Antibody (TAB-152) in WB

Anti-Human CD40 Recombinant Antibody (TAB-152) (CAT# TAB-152)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 1 Anti-CD40 Antibody (TAB-126CL) in WB

Human Anti-CD40 Recombinant Antibody (TAB-126CL) (CAT# TAB-126CL)
Application: Block, Cyt, FuncS, Inhib

Figure 1 Anti-Human CD41 Recombinant Antibody (TP-100CL) in ELISA

Abciximab (CAT# TP-100CL)
Application:

Figure 1 Anti-LYZ Recombinant Antibody (PABW-023) in ELISA

Human Anti-LYZ Recombinant Antibody (clone HuLys11) (CAT# PABW-023)
Application: WB, ELISA

Figure 1 Human TIM3 Recombinant Antibody (TAB-0366CL) in ELISA

Anti-Human TIM3 Recombinant Antibody (TSR-022) (CAT# TAB-0366CL)
Application: FC, FuncS

Figure 1 Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17), gggc tag (TAB-0961CL-F(E)) in SDS-PAGE

Anti-Human PDCD1 Recombinant Antibody Fab Fragment (PD1-17) (CAT# TAB-0961CL-F(E))
Application: ELISA

Figure 1 Anti-CD33 Antibody (TAB-119LC) in ELISA

Mouse Anti-CD33 Recombinant Antibody (TAB-119LC) (CAT# TAB-119LC)
Application: ELISA, IF, RIA

Figure 1 Anti-Human CDCP1 Recombinant Antibody (TAB-403LC) in SDS-PAGE

Anti-Human CDCP1 Recombinant Antibody (25A11) (CAT# TAB-403LC)
Application: FC, FuncS, IHC

Figure 1 Anti-Human IL23A Antibody (TAB-620LC) in WB

Anti-human IL23A Recombinant Antibody (TAB-620LC) (CAT# TAB-620LC)
Application: ELISA

Figure 1 Anti-SARS-CoV S Therapeutic Antibody (CR3022) (MRO-1214LC) in WB

Anti-SARS-CoV S Recombinant Antibody (MRO-1214LC) (CAT# MRO-1214LC)
Application: Neut, ELISA

Figure 1 Mouse Anti-ERBB2 Recombinant Antibody (NEUT-737CQ) in SDS-PAGE

Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4) (CAT# NEUT-737CQ)
Application: Block, IP, IF, FC

Figure 1 Anti-CD40 Antibody (MOB-120CQ) in WB

Human Anti-CD40 Recombinant Antibody (MOB-120CQ) (CAT# MOB-120CQ)
Application: ELISA, IHC, IF, IP, FC, FuncS

Figure 1 Human Anti-HIV-1 gp160 Recombinant Antibody (MRO-3786CQ) in SDS-PAGE

Human Anti-HIV-1 gp160 Recombinant Antibody (MRO-3786CQ) (CAT# MRO-3786CQ)
Application: FuncS

Figure 1 Human Anti-PEG Recombinant Antibody (FAMAB-1525CQ) in SDS-PAGE

Human Anti-PEG Recombinant Antibody (clone E11) (CAT# FAMAB-1525CQ)
Application: WB, ELISA, FC

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

  • 0
  • 0
Cart
    Inquiry
    Go to compare

    Go to compare