Anti-Mesothelin (MDX-1382)-Duocarmycins ADC (MDX-1204)
CAT#: ADC-L013
This ADC product is composed of an anti-mesothelin antibody (MDX-1382) conjuagated to Duocarmycins (MDX-1382-Duocarmycins). It has demonstrated a response in ovarian and pancreatic cancers treatment by a MOA (Mechanism of Action) of Bind to DNA minor groove and cause DNA damage.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
Normal Tissue
Figure 2 Fallopian tube
Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
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Specifications
- Antibody Overview
- Fully human IgG1 monoclonal antibody that binds to mesothelin
- Clone
- MDX-1382
- Antibody Conjugation
- Human
- Linker
- cleavable di-peptide linker
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- Duocarmycins
- Drug Class/Description
- Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized
Target
- Introduction
- This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
- Alternative Names
- MPF; SMRP
- Gene ID
- 10232
- UniProt ID
- Q13421
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| TAB-0833CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0833CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0834CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0834CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0835CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0835CL-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-2427LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-2427LY-F(E)) | ELISA | Human Fab |
| HPAB-2428LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-2428LY-F(E)) | ELISA | Human Fab |
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| HPAB-2736LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-2736LY-F(E)) | ELISA, FC | Human Fab |
| HPAB-2737LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-2737LY-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| MHC-CN1052 | A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0155-YC-S(P) | Human Anti-MSLN Recombinant Antibody (clone M/YC-16); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-M0157-YC-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-M0157-YC-S(P)) | FuncS | Rabbit scFv |
| HPAB-M0158-YC-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-M0158-YC-S(P)) | FuncS | Humanized scFv |
| HPAB-M0159-YC-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-M0159-YC-S(P)) | FuncS | Rabbit scFv |
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|---|---|---|---|
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