Anti-Mesothelin (MDX-1382)-Duocarmycins ADC (MDX-1204) (CAT#: ADC-L013)

• Antibody Overview
• Fully human IgG1 monoclonal antibody that binds to mesothelin

• Clone
• MDX-1382

• Antibody Conjugation
• Human

• Linker
• cleavable di-peptide linker

• Linker Class/Description
• Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• Duocarmycins

• Drug Class/Description
• Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized

• Introduction
• This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

• Alternative Names
• MPF; SMRP

• Gene ID
• 10232

• UniProt ID
• Q13421

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