Anti-Mesothelin (MF-T)-DM4 ADC (BAY 94-9343) (CAT#: ADC-L009)
This ADC product is composed of an anti-mesothelin antibody (clone MF-T) conjuagated via a disulfide linker to DM4 (MF-T-disulfide-DM4). It has demonstrated a response in ovarian and pancreatic cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
Figure 2 Fallopian tube
(Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
(Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
Specifications
- Antibody Overview
- Fully human IgG1 monoclonal antibody that binds to mesothelin
- Clone
- MF-T
- Antibody Conjugation
- Human
- Linker
- disulfide
- Linker Class/Description
- Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
- Alternative Names
- MPF; SMRP
- Gene ID
- 10232
- UniProt ID
- Q13421
Downloads
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See other products for "MSLN"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-009 | Recombinant Anti-human MSLN VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| HPAB-M0391-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (NbA1/G3A) | ELISA, FC, IF | Llama VHH |
| HPAB-M0392-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (NbC6/F10) | ELISA, FC, IF | Llama VHH |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201 | Anti-Human Mesothelin Recombinant Antibody (Amatuximab) | IP, IF, FuncS, FC, Neut, ELISA, IHC | IgG1 - kappa |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G052E | Anti-MSLN immunotoxin RG7787 (Fab)-PE | Cytotoxicity assay, Function study | |
| AGTO-G053E | Anti-Msln immunotoxin (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-L035E | anti-MSLN immunotoxin K1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L063E | anti-MSLN immunotoxin 8B35 (scFv)-PE | Cytotoxicity assay, Functional assay |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-658 | Mouse Anti-MSLN Recombinant Antibody (clone MORAb-009) | WB | Mouse IgG |
| HPAB-0041-CN | Mouse Anti-MSLN Recombinant Antibody (HPAB-0041-CN) | FC, WB, ELISA | Mouse IgG |
| HPAB-0042-CN | Mouse Anti-MSLN Recombinant Antibody (HPAB-0042-CN) | FC, WB, ELISA | Mouse IgG |
| HPAB-0043-CN | Mouse Anti-MSLN Recombinant Antibody (HPAB-0043-CN) | FC, WB, ELISA | Mouse IgG |
| HPAB-0044-CN | Human Anti-MSLN Recombinant Antibody (HPAB-0044-CN) | FC, WB, ELISA | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-652 | Mouse Anti-MSLN Recombinant Antibody (clone MORAb-009); scFv Fragment | WB | Mouse scFv |
| HPAB-0041-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0041-CN-S(P)) | FC, WB, ELISA | Mouse scFv |
| HPAB-0042-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0042-CN-S(P)) | FC, WB, ELISA | Mouse scFv |
| HPAB-0646-CN-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0646-CN-S(P)) | WB, ELISA, FC | Human scFv |
| HPAB-S0098-YC-S(P) | Mouse Anti-MSLN Recombinant Antibody (clone SS); scFv Fragment | ELISA | Mouse scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0833CL | Human Anti-MSLN Recombinant Antibody (TAB-0833CL) | ELISA, FuncS, Activ, FC | Human IgG1 |
| TAB-0834CL | Human Anti-MSLN Recombinant Antibody (TAB-0834CL) | ELISA, FuncS, FC, SPR, Inhib | Human IgG1, κ |
| TAB-0835CL | Human Anti-MSLN Recombinant Antibody (TAB-0835CL) | ELISA, FC, FACS, Inhib | Human IgG1, λ |
| TAB-0833CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0833CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0833CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0833CL-F(E)) | ELISA, FC | Human Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0376MZ | Chicken Anti-MSLN Polyclonal IgY | WB | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2302 | Hi-Affi™ Recombinant Rabbit Anti-MSLN Monoclonal Antibody (DS2302AB) | WB | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0706-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0706-CN-F(E)) | WB, ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-0707-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0707-CN-F(E)) | WB, ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-0708-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0708-CN-F(E)) | WB, ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-0442LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0442LY-F(E)) | ELISA, FC, IHC, WB | Human Fab |
| HPAB-0443LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0443LY-F(E)) | ELISA, FC, IHC, WB | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-201 | Afuco™ Anti-MSLN ADCC Recombinant Antibody (Amatuximab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1049 | PE-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-CN1050 | APC-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-CN1051 | FITC-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-YF553 | A*01:01/Human Mesothelin (TLDTLTAFY) MHC Pentamer | FCM | |
| MHC-YF554 | A*02:01/Human Mesothelin (SLLFLLFSL) MHC Pentamer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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