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Anti-Human RGMA Therapeutical Antibody (CAT#: TAB-748CL)

Recombinant monoclonal antibody expressed in CHO binding to Human RGMA. The RGMA binding proteins, particularly monoclonal antibodiess have the ability to bind to RGMA, and therefore neutralize the function of RGMA, for use in the treatment of retinal nerve fiber layer (RNFL) degeneration.


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Subcellular Location
Figure 1 IF staining of human cell line RH-30
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39880/if_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/44222/1038_D3_2_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32697_B_7_5.jpg
Figure 4 Colon
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_7_3.jpg
Figure 5 Liver
Figure 5 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_9_4.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_9_5.jpg
Figure 7 Testis
Figure 7 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AF22, BEWO, MOLT-4, NTERA-2, REH)
Figure 8 RNA cell line category: Cell line enhanced (AF22, BEWO, MOLT-4, NTERA-2, REH)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182175-RGMA

Specifications

  • Derivation
  • Humanized
  • Type
  • Antibody
  • Species Reactivity
  • Human
  • Related Disease
  • Retinal Nerve Fiber Layer (RNFL) Degeneration

Product Property

  • Purity
  • >95% as determined by analysis by RP-HPLC
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

Target

  • Alternative Names
  • RGMA; repulsive guidance molecule family member a; RGM; repulsive guidance molecule A; RGM domain family, member A

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "RGMA"

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3059 Hi-Affi™ Recombinant Rabbit Anti-RGMA Monoclonal Antibody (DS3059AB) WB, ICC/IF IgG

Human Antibody

CAT Product Name Application Type
TAB-421CQ Anti-Human RGMA Recombinant Antibody (Elezanumab) ELISA, IHC, FC, IP, IF, FuncS IgG1, λ1

Neuroscience Antibody

CAT Product Name Application Type
NS-070CN Human Anti-RGMA Recombinant Antibody (NS-070CN) ELISA, Neut, FuncS Human IgG
NS-071CN Human Anti-RGMA Recombinant Antibody (NS-071CN) ELISA Human IgG
NS-072CN Human Anti-RGMA Recombinant Antibody (NS-072CN) ELISA Human IgG
NS-073CN Human Anti-RGMA Recombinant Antibody (NS-073CN) FC, ELISA Human IgG
NS-074CN Human Anti-RGMA Recombinant Antibody (NS-074CN) FC, ELISA Human IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0635-CN Rat Anti-RGMA Recombinant Antibody (HPAB-0635-CN) ELISA, FC, IF Rat IgG
HPAB-0636-CN Rat Anti-RGMA Recombinant Antibody (HPAB-0636-CN) ELISA Rat IgG
HPAB-0637-CN Human Anti-RGMA Recombinant Antibody (HPAB-0637-CN) ELISA, FC, IF Chimeric (rat/human) IgG1
HPAB-0638-CN Human Anti-RGMA Recombinant Antibody (HPAB-0638-CN) ELISA, FC, IF Humanized IgG
HPAB-0617YY Human Anti-RGMA Recombinant Antibody (HPAB-0617YY) ELISA, FuncS Humanized IgG2b, κ

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0635-CN-S(P) Rat Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0635-CN-S(P)) ELISA, FC, IF Rat scFv
HPAB-0636-CN-S(P) Rat Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0636-CN-S(P)) ELISA Rat scFv
HPAB-0637-CN-S(P) Mouse Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0637-CN-S(P)) ELISA, FC, IF Mouse scFv
HPAB-0638-CN-S(P) Human Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0638-CN-S(P)) ELISA, FC, IF Humanized scFv
HPAB-0617YY-S(P) Human Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0617YY-S(P)) ELISA, FuncS Humanized scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0635-CN-F(E) Rat Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0635-CN-F(E)) ELISA, FC, IF Rat Fab
HPAB-0636-CN-F(E) Rat Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0636-CN-F(E)) ELISA Rat Fab
HPAB-0637-CN-F(E) Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0637-CN-F(E)) ELISA, FC, IF Chimeric (rat/human) Fab
HPAB-0638-CN-F(E) Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0638-CN-F(E)) ELISA, FC, IF Humanized Fab
HPAB-0617YY-F(E) Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0617YY-F(E)) ELISA, FuncS Humanized Fab

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-421CQ Afuco™ Anti-RGMA ADCC Recombinant Antibody (Elezanumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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