Anti-Human RGMA Antibody, Research Grade Biosimilar

Name: Anti-Human RGMA Antibody, Research Grade Biosimilar
SKU: TAB-748CL
Rating: 5 (1 reviews)

CAT#: TAB-748CL

Recombinant monoclonal antibody expressed in CHO binding to Human RGMA. The RGMA binding proteins, particularly monoclonal antibodiess have the ability to bind to RGMA, and therefore neutralize the function of RGMA, for use in the treatment of retinal nerve fiber layer (RNFL) degeneration.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line RH-30

Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39880/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & nuclear bodies.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44222/1038_D3_2_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32697_B_7_5.jpg

Normal Tissue Figure 4 Colon

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_7_3.jpg

Normal Tissue Figure 5 Liver

Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_9_4.jpg

Normal Tissue Figure 6 Kidney

Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_9_5.jpg

Normal Tissue Figure 7 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_6_6.jpg

RNA Expression Figure 8 RNA cell line category: Cell line enhanced (AF22, BEWO, MOLT-4, NTERA-2, REH)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182175-RGMA

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Specifications

Derivation
Humanized

Type
Antibody

Species Reactivity
Human

Related Disease
Retinal Nerve Fiber Layer (RNFL) Degeneration

Product Property

Purity
>95% as determined by analysis by RP-HPLC

Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.

Target

Alternative Names
RGMA; repulsive guidance molecule family member a; RGM; repulsive guidance molecule A; RGM domain family, member A

Gene ID
56963

UniProt ID
Q96B86

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Related Signaling Pathways

TGF-β Signaling Pathway

Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-748CL.pdf

MSDS

MSDS - TAB-748CL.pdf

COA

Certificate of Analysis Lookup

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See other products for "RGMA"

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TAB-421CQ	Anti-Human RGMA Recombinant Antibody (TAB-421CQ)	ELISA, IHC, FC, IP, IF, FuncS	IgG1, λ1

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NS-070CN	Human Anti-RGMA Recombinant Antibody (NS-070CN)	ELISA, Neut, FuncS	Human IgG
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NS-072CN	Human Anti-RGMA Recombinant Antibody (NS-072CN)	ELISA	Human IgG
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HPAB-0635-CN	Rat Anti-RGMA Recombinant Antibody (HPAB-0635-CN)	ELISA, FC, IF	Rat IgG
HPAB-0636-CN	Rat Anti-RGMA Recombinant Antibody (HPAB-0636-CN)	ELISA	Rat IgG
HPAB-0637-CN	Human Anti-RGMA Recombinant Antibody (HPAB-0637-CN)	ELISA, FC, IF	Chimeric (rat/human) IgG1
HPAB-0638-CN	Human Anti-RGMA Recombinant Antibody (HPAB-0638-CN)	ELISA, FC, IF	Humanized IgG
HPAB-0617YY	Human Anti-RGMA Recombinant Antibody (HPAB-0617YY)	ELISA, FuncS	Humanized IgG2b, κ

CAT	Product Name	Application	Type
HPAB-0635-CN-S(P)	Rat Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0635-CN-S(P))	ELISA, FC, IF	Rat scFv
HPAB-0636-CN-S(P)	Rat Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0636-CN-S(P))	ELISA	Rat scFv
HPAB-0637-CN-S(P)	Mouse Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0637-CN-S(P))	ELISA, FC, IF	Mouse scFv
HPAB-0638-CN-S(P)	Human Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0638-CN-S(P))	ELISA, FC, IF	Humanized scFv
HPAB-0617YY-S(P)	Human Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0617YY-S(P))	ELISA, FuncS	Humanized scFv

CAT	Product Name	Application	Type
HPAB-0635-CN-F(E)	Rat Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0635-CN-F(E))	ELISA, FC, IF	Rat Fab
HPAB-0636-CN-F(E)	Rat Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0636-CN-F(E))	ELISA	Rat Fab
HPAB-0637-CN-F(E)	Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0637-CN-F(E))	ELISA, FC, IF	Chimeric (rat/human) Fab
HPAB-0638-CN-F(E)	Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0638-CN-F(E))	ELISA, FC, IF	Humanized Fab
HPAB-0617YY-F(E)	Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0617YY-F(E))	ELISA, FuncS	Humanized Fab

CAT	Product Name	Application	Type
AFC-TAB-421CQ	Afuco™ Anti-RGMA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-421CQ)	ELISA, IHC, FC, IP, IF, FuncS	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0425-FY173	Human Anti-RGMA scFv-Fc Chimera (VS-0425-FY173)	ELISA, Inhib	Human IgG1, scFv-Fc

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