The antibody specifically bind human RSPO3 proteins and modulate β-catenin activity. The antibody inhibits β-catenin signaling.
Figure 1 Inhibition of tumor growth with anti-RSPO anti bodies.
LU25 NSCLC lung tumor cells were injected subcu taneously into NOD/SCID mice. Mice were treated with anti RSPO3 antibody 131R008 (-▲-), paclitaxel alone (-○-), a combination of anti-RSPO3 antibody 131R008 and paclitaxel (-●-), or a control antibody (-■-). Data is shown as tumor volume (mm) over days post-treatment.
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