Rat Anti-RSPO3 Recombinant Antibody (clone 15F3) (CAT#: HPAB-M0620-YC)
Provided herein is an antibody 15F3 that binds to human RSPO3, cyno RSPO3 and murine RSPO3 with a Kd of 0.845 nM, 0.576 nM and 0.926 nM, respectively. The antibody has a half-life of at least 6 days and reduce tumor growth.
Specific Inquiry
FuncS
Figure 1 Pharmacokinetic studies of the humanized antibodies hu4A6.L4H2, hu11C10.L5H2, hu15F3.L4H2, antibody 5D6, and control anti-gD in Balb/c nude mice following a single 5 mg/kg IV dose.
Mean serum concentrations of serum antibodies are shown over time. The 4A6, 15F3, and 11C10 antibodies demonstrated biphasic disposition profiles typical of IgG1 antibodies and were indistinguishable from the control anti-gD antibody.
FuncS
Figure 2 Pharmacokinetic studies of the humanized antibodies hu4A6.L4H2, hu11C10.L5H2, hu15F3.L4H2 following a single bolus dose of 10 mg/kg.
Specifications
- Immunogen
- Human RSPO3 protein
- Host Species
- Rat
- Type
- Rat IgG2
- Specificity
- Human RSPO3
- Species Reactivity
- Human, Cynomolgus, Mouse
- Clone
- 15F3
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for ELISA, Functional Assay. For details, refer to Published Data.
Target
- Alternative Names
- R-Spondin 3; Thrombospondin Type-1 Domain-Containing Protein 2; Thrombospondin, Type I, Domain Containing 2; Protein With TSP Type-1 Repeat; Roof Plate-Specific Spondin-3; THSD2; PWTSR;
- Gene ID
- 84870
- UniProt ID
- Q9BXY4
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone 15F3"
See other products for "RSPO3"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2146-VHH | Recombinant Anti-Human RSPO3 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-351CT | Humanized Anti-RSPO3 Recombinant Antibody (TAB-351CT) | WB, ELISA, Neut, FC, IHC, IP | Humanized IgG |
| TAB-351CT-S(P) | Humanized Anti-RSPO3 Recombinant Antibody; scFv Fragment (TAB-351CT-S(P)) | WB, ELISA, Neut, FC, IHC, IP | Humanized scFv |
| TAB-351CT-F(E) | Humanized Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-351CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Humanized Fab |
| TAB-449CQ | Anti-Human RSPO3 Recombinant Antibody (Rosmantuzumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-350CT-S(P) | Mouse Anti-RSPO3 Recombinant Antibody; scFv Fragment (TAB-350CT-S(P)) | WB, ELISA, Neut, FC, IHC, IP | Mouse scFv |
| TAB-353CT-S(P) | Mouse Anti-RSPO3 Recombinant Antibody; scFv Fragment (TAB-353CT-S(P)) | WB, ELISA, Neut, FC, IHC, IP | Mouse scFv |
| TAB-354CT-S(P) | Mouse Anti-RSPO3 Recombinant Antibody; scFv Fragment (TAB-354CT-S(P)) | WB, ELISA, Neut, FC, IHC, IP | Mouse scFv |
| TAB-355CT-S(P) | Mouse Anti-RSPO3 Recombinant Antibody; scFv Fragment (TAB-355CT-S(P)) | WB, ELISA, Neut, FC, IHC, IP | Mouse scFv |
| TAB-356CT-S(P) | Mouse Anti-RSPO3 Recombinant Antibody; scFv Fragment (TAB-356CT-S(P)) | WB, ELISA, Neut, FC, IHC, IP | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0036CQ | Human Anti-RSPO3 Recombinant Antibody (clone h131R008) | ELISA, Inhib | Humanized IgG1, κ |
| HPAB-0037CQ | Human Anti-RSPO3 Recombinant Antibody (clone h131R007) | ELISA, Inhib, FC | Humanized IgG2, κ |
| HPAB-0038CQ | Mouse Anti-RSPO3 Recombinant Antibody (clone 131R003) | ELISA, Inhib | Mouse IgG2, κ |
| HPAB-M0618-YC | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6) | ELISA | Rat IgG2a |
| HPAB-M0619-YC | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10) | ELISA | Rat IgG2 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0036CQ-F(E) | Human Anti-RSPO3 Recombinant Antibody (clone h131R008); Fab Fragment | ELISA, Inhib | Humanized Fab |
| HPAB-0037CQ-F(E) | Human Anti-RSPO3 Recombinant Antibody (clone h131R007); Fab Fragment | ELISA, Inhib | Humanized Fab |
| HPAB-0038CQ-F(E) | Mouse Anti-RSPO3 Recombinant Antibody (clone 131R003); Fab Fragment | ELISA, Inhib | Mouse Fab, κ |
| HPAB-M0618-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6); Fab Fragment | ELISA | Rat Fab |
| HPAB-M0619-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10); Fab Fragment | ELISA | Rat Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0618-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6); scFv Fragment | ELISA | Rat scFv |
| HPAB-M0619-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10); scFv Fragment | ELISA | Rat scFv |
| HPAB-M0620-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 15F3); scFv Fragment | ELISA | Rat scFv |
| HPAB-M0621-YC-S(P) | Human Anti-RSPO3 Recombinant Antibody (clone hu4A6.L4H2); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-M0622-YC-S(P) | Human Anti-RSPO3 Recombinant Antibody (clone hu11C10.L5H2); scFv Fragment | ELISA, FuncS | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-449CQ | Afuco™ Anti-RSPO3 ADCC Recombinant Antibody (Rosmantuzumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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