Anti-Human RTN4 Recombinant Antibody (11C7)
CAT#: TAB-531MZ
This antibody 11C7 is capable of binding to the human NogoA polypeptide or human NiG or human NiG-D20 or human NogoA_623-640. Such a binding molecule can be potentially used in treatment studies of diseases associated with nerve repair.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in seminiferous ducts cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6_selected.jpg
Normal Tissue
Figure 3 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_A_6_6_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_B_8_5.jpg
Normal Tissue
Figure 5 Cerebellum
Cells in granular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_B_7_8.jpg
Normal Tissue
Figure 6 Colon
Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_9_3.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (HHSteC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115310-RTN4
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Specifications
- Immunogen
- Synthetic NogoA peptides
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 11C7
- Applications
- ELISA, ICC
- Related Disease
- Diseases associated with nerve repair
Applications
- Application Notes
- The antibody was validated for ELISA, Immunocytochemistry. For details, refer to Published Data.
Target
- Alternative Names
- RTN4; reticulon 4; ASY; NSP; NOGO; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B; Nogo-C; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545; reticulon-4; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog
- Gene ID
- 57142
- UniProt ID
- Q9NQC3
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Transformative Research Tool
The Anti-Human RTN4 Recombinant Antibody has been instrumental in advancing our lab's research on nerve repair. Its specificity allows us to pinpoint interactions that were previously elusive. Consistency across batches is commendable, ensuring reliable results over repeated experiments. We have truly seen the value it adds when deciphering complex neural pathways.
Reliable Performance in ICC
I have used this antibody extensively for immunocytochemistry projects; it delivers robust and consistent stains. The clear visualization in endoplasmic reticulum studies speaks volumes of its effectiveness. Even with high sample throughput, the repeatability remains exceptional, marking it as a top-tier choice for in-depth cellular analysis.
Ideal for Neurobiology Studies
As a researcher in neurobiology, the RTN4 antibody has exceeded expectations. Its high affinity and specificity have been crucial in quantifying NogoA-related pathways, crucial for studying inhibitory signals in axon guidance. It has certainly gained a fixture in our lab protocols for complex neural tissue studies.
Q&As
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What applications can this antibody be used for?
A: The Anti-Human RTN4 Recombinant Antibody (11C7) is useful for ELISA and Immunocytochemistry (ICC) applications. It provides researchers with reliable tools to study specific cellular pathways involving nerve repair and RTN4 interactions.
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What are the alternative names of RTN4 this antibody targets?
A: This antibody targets the protein known by several names, including Reticulon 4, NogoA, and neurite outgrowth inhibitor among others. These alternative names illustrate the protein's diverse functions across various neural processes.
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How does this antibody support nerve repair research?
A: By binding specifically to the NogoA polypeptide, the antibody allows scientists to explore mechanisms involved in nerve regeneration and repair. Understanding these interactions could ultimately provide insights into neurological recovery processes.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-531MZ, RRID: AB_3111970)
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone 11C7"
- CAT
- Product Name
See other products for "RTN4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-242 | Anti-Human RTN-4 Recombinant Antibody (TAB-242) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-903 | Anti-Human Nogo-A Recombinant Antibody (TAB-903) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 |
| TAB-534MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-534MZ-F(E)) | ELISA, FC | Humanized Fab |
| TAB-535MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-535MZ-F(E)) | ELISA, FC | Humanized Fab |
| TAB-536MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-536MZ-F(E)) | ELISA, FC | Humanized Fab |
| TAB-537MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-537MZ-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-532MZ | Mouse Anti-RTN4 Recombinant Antibody (TAB-532MZ) | ELISA, FC | Mouse IgG |
| TAB-531MZ-S(P) | Anti-Human RTN4 Recombinant Antibody scFv Fragment (11C7) | ELISA, ICC | |
| TAB-532MZ-S(P) | Mouse Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-532MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-531MZ-F(E) | Anti-Human RTN4 Recombinant Antibody Fab Fragment (11C7) | ELISA, ICC | |
| TAB-532MZ-F(E) | Mouse Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-532MZ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-533MZ | Human Anti-RTN4 Recombinant Antibody (TAB-533MZ) | ELISA, FC | Chimeric (mouse/human) IgG |
| TAB-533MZ-S(P) | Mouse Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-533MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-533MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-533MZ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3139 | Hi-Affi™ Recombinant Rabbit Anti-RTN4 Monoclonal Antibody (DS3139AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-186CQ | Mouse Anti-RTN4 Antibody | ELISA, WB | Mouse IgG1 |
| HPAB-0294CQ | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6) | ELISA, WB | Mouse IgG1 |
| HPAB-0295CQ | Human Anti-RTN4 Recombinant Antibody (clone h3A6) | ELISA, WB | Human IgG4 |
| HPAB-0047-WJ | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2) | ELISA, WB, Inhib, IHC, IF | Mouse IgG |
| HPAB-0901-FY | Human Anti-RTN4 Recombinant Antibody (HPAB-0901-FY) | ELISA, Neut | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0294CQ-F(E) | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0295CQ-F(E) | Human Anti-RTN4 Recombinant Antibody (clone h3A6); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0047-WJ-F(E) | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0901-FY-S(P) | Human Anti-RTN4 Recombinant Antibody; scFv Fragment (HPAB-0901-FY-S(P)) | ELISA, Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0294CQ-S(P) | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-0295CQ-S(P) | Human Anti-RTN4 Recombinant Antibody (clone h3A6); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-0047-WJ-S(P) | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-0901-FY-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (HPAB-0901-FY-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-903 | Afuco™ Anti-RTN4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-903) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-242 | Afuco™ Anti-RTN4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-242) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY158 | Mouse Anti-RTN4 (clone 11C7) scFv-Fc Chimera | ELISA, ICC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC538 | Recombinant Anti-RTN4 Vesicular Antibody, EV Displayed (VS-0425-YC538) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6264 | Anti-RTN4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6265 | Anti-Rat RTN4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6266 | Anti-Mouse RTN4 Immunohistochemistry Kit | IHC |
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