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RTN4
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
Protein class
Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Muller glia cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (HHSteC)
Interaction
Binds to RTN4R (PubMed:19052207). Interacts with ATL1 (PubMed:19665976). Interacts with TMEM170A (PubMed:19665976, PubMed:26906412). Interacts with RTN4IP1 (By similarity). [Isoform A]: Interacts in trans with CNTNAP1 (By similarity). Interacts with REEP5 (PubMed:32075961). [Isoform B]: Homodimer (PubMed:27786289). Interacts with BAD/Bcl-xl and BCL2. Interact with RTN3 (PubMed:12811824, PubMed:16979658). Interacts with NGBR (PubMed:16835300). Interacts with SPTLC1 (By similarity). Interacts with GRAMD4 (By similarity). Interacts with CDH5 (PubMed:21183689). Interacts with BACE1 and BACE2 (PubMed:15286784, PubMed:16965550). Interacts with REEP5 (PubMed:32075961). [Isoform C]: Interacts with BACE1 and BACE2 (PubMed:15286784, PubMed:16965550). Interacts with TMEM33 (PubMed:25612671).
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgM, κ
- Application: WB, ELISA, IF, IP
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, FC
- Mouse Anti-RTN4 Antibody (MOB-186CQ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: ELISA, WB
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- Species Reactivity: Human
- Application: WB, IHC-P, IHC-Fr
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
- Human Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-536MZ-S(P)) (TAB-536MZ-S(P))
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC
- Human Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-535MZ-S(P)) (TAB-535MZ-S(P))
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC
- Human Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-534MZ-S(P)) (TAB-534MZ-S(P))
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC
- Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-537MZ-F(E)) (TAB-537MZ-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
- Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-536MZ-F(E)) (TAB-536MZ-F(E))
-
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
- Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-535MZ-F(E)) (TAB-535MZ-F(E))
-
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
- Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-534MZ-F(E)) (TAB-534MZ-F(E))
-
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
- Mouse Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-533MZ-S(P)) (TAB-533MZ-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-532MZ-S(P)) (TAB-532MZ-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Anti-Human RTN4 Recombinant Antibody scFv Fragment (11C7) (TAB-531MZ-S(P))
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- Application: ELISA, ICC
- Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-533MZ-F(E)) (TAB-533MZ-F(E))
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- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: ELISA, FC
- Mouse Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-532MZ-F(E)) (TAB-532MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Anti-Human RTN4 Recombinant Antibody Fab Fragment (11C7) (TAB-531MZ-F(E))
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- Application: ELISA, ICC
- Anti-Human RTN4 Recombinant Antibody (TAB-541CL)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Antibody
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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For Research Use Only. Not For Clinical Use.