Mouse Anti-RTN4 (clone 11C7) scFv-Fc Chimera
CAT#: VS-0425-FY158
This antibody targets RTN4 (Reticulon 4), also known as Nogo. RTN4 is a protein that inhibits neurite outgrowth and axonal regeneration in the central nervous system. An anti-RTN4 scFv-FC could be used to block this inhibitory activity, potentially promoting neural repair.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in seminiferous ducts cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6_selected.jpg
Normal Tissue
Figure 3 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_A_6_6_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_B_8_5.jpg
Normal Tissue
Figure 5 Cerebellum
Cells in granular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_B_7_8.jpg
Normal Tissue
Figure 6 Colon
Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_9_3.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (HHSteC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115310-RTN4
❮
❯
Specifications
- Immunogen
- The immunogen is synthetic NogoA peptides.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human RTN4
- Species Reactivity
- Human
- Clone
- 11C7
- Applications
- ELISA, Immunocytochemistry
- Related Disease
- Temporal Lobe Epilepsy; Anosognosia
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Reticulon 4; Neuroendocrine-Specific Protein C Homolog; Neurite Outgrowth Inhibitor; Foocen; RTN-X; NOGO; NSP; Neuroendocrine-Specific Protein; Neurite Growth Inhibitor 220; My043 Protein; Nogo Protein; Human NogoA; Reticulon 5
- Gene ID
- 57142
- UniProt ID
- Q9NQC3
- Long Name
- Reticulon 4
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Ubiquitination at Lys1090, Lys1104, and Lys1171
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 5 sites, 1 O-linked glycan (5 sites)
- Protein Refseq
- NP_001308789.1
- Function
- Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules.
They regulate membrane morphogenesis in the ER by promoting tubular ER production.
They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins.
However each isoform have specific functions mainly depending on their tissue expression specificities (Probable).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-FY158. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 11C7"
- CAT
- Product Name
See other products for "RTN4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2437z | Mouse Anti-RTN4 Recombinant Antibody (clone 28B12) | WB, ELISA, IF, IP | Mouse IgM, κ |
| MOB-2424CT | Recombinant Mouse anti-Human RTN4 Monoclonal antibody (9XH27) | WB, IHC-P, IHC-Fr | |
| HPAB-0294CQ | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6) | ELISA, WB | Mouse IgG1 |
| HPAB-0047-WJ | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2) | ELISA, WB, Inhib, IHC, IF | Mouse IgG |
| VS3-XY3491 | Rabbit Anti-RTN4 Recombinant Antibody (clone R05-4C9) | WB, IHC-P, ICC, IF, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-242 | Anti-Human RTN-4 Recombinant Antibody (TAB-242) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-903 | Anti-Human Nogo-A Recombinant Antibody (TAB-903) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 |
| TAB-534MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-534MZ-F(E)) | ELISA, FC | Humanized Fab |
| TAB-535MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-535MZ-F(E)) | ELISA, FC | Humanized Fab |
| TAB-536MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-536MZ-F(E)) | ELISA, FC | Humanized Fab |
| TAB-537MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-537MZ-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-531MZ | Anti-Human RTN4 Recombinant Antibody (11C7) | ELISA, ICC | |
| TAB-531MZ-S(P) | Anti-Human RTN4 Recombinant Antibody scFv Fragment (11C7) | ELISA, ICC | |
| TAB-532MZ-S(P) | Mouse Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-532MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-531MZ-F(E) | Anti-Human RTN4 Recombinant Antibody Fab Fragment (11C7) | ELISA, ICC | |
| TAB-532MZ-F(E) | Mouse Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-532MZ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-533MZ | Human Anti-RTN4 Recombinant Antibody (TAB-533MZ) | ELISA, FC | Chimeric (mouse/human) IgG |
| TAB-533MZ-S(P) | Mouse Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-533MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-533MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-533MZ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3139 | Hi-Affi™ Recombinant Rabbit Anti-RTN4 Monoclonal Antibody (DS3139AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0294CQ-F(E) | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0295CQ-F(E) | Human Anti-RTN4 Recombinant Antibody (clone h3A6); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0047-WJ-F(E) | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0901-FY-S(P) | Human Anti-RTN4 Recombinant Antibody; scFv Fragment (HPAB-0901-FY-S(P)) | ELISA, Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0294CQ-S(P) | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-0295CQ-S(P) | Human Anti-RTN4 Recombinant Antibody (clone h3A6); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-0047-WJ-S(P) | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-0901-FY-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (HPAB-0901-FY-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-903 | Afuco™ Anti-RTN4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-903) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-242 | Afuco™ Anti-RTN4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-242) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC538 | Recombinant Anti-RTN4 Vesicular Antibody, EV Displayed (VS-0425-YC538) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6264 | Anti-RTN4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6265 | Anti-Rat RTN4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6266 | Anti-Mouse RTN4 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, WB
Application: Block, Cyt, FuncS, Inhib
Application: WB, Neut, FuncS
-3.jpg)
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
-3.jpg)
Application: Neut
Application: ELISA, FC, IF, IHC, WB
-2.png)
Application: ELISA, WB
Application: FC
Application: ELISA, Cyt, PP, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
