Afuco™ Anti-RTN4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-903)

CAT#: AFC-TAB-903

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human Nogo-A. It is a monoclonal antibody designed for the treatment of ALS and multiple sclerosis. It targets a protein called Neurite Outgrowth Inhibitor (NOGO-A) or Reticulon 4. NOGO-A is a protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. NOGO-A is found at higher than normal levels in persons with MND.

Gene Expression
Figure 1 IF staining of human cell line U-2 OS Figure 2 IHC staining of human testis Figure 3 IHC staining of human testis Figure 4 Cerebral cortex Figure 5 Cerebellum Figure 6 Colon Figure 7 Testis Figure 8 RNA cell line category: Cell line enhanced (HHSteC)

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Humanized (from mouse)
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Applications
  • IF, IP, Neut, FuncS, ELISA, FC
  • Conjugate
  • Unconjugated
  • Generic Name
  • Ozanezumab
  • Related Disease
  • Multiple sclerosis (MS)

Product Property

  • Purity
  • >95% by SDS-PAGE
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • NOGO; NSP CL; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog; NSP; NOGOC;
REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
Inquiry
Navs

Customer Review

Submit a review or a question

There are currently no Customer reviews or questions for AFC-TAB-903. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Article title:
DOI/PubMed URL:
Email:
Name:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Biosimilar Overview

Please refer to Ozanezumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ozanezumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Ozanezumab"

DrugMonitor™ Anti-Ozanezumab Antibody (VS-1224-YC870)
Ozanezumab has been utilized in clinical trials exploring the treatment of Multiple Sclerosis, Amyotrophic Lateral Sclerosis, and Relapsing-Remitting Multiple Sclerosis. The DrugMonitor™ Anti-Ozanezumab Antibody (VS-1224-YC870) is an anti-drug antibody (ADA) against Ozanezumab. This drug-based antibody is raised in mice immunized with the Ozanezumab. The anti-Ozanezumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Ozanezumab in samples.

See other products for "RTN4"

Select a product category from the dropdown menu below to view related products.

CAT Product Name Application Type
TAB-242 Anti-Human RTN-4 Recombinant Antibody (TAB-242) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG4 - kappa
CAT Product Name Application Type
AFC-TAB-242 Afuco™ Anti-RTN4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-242) ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
CAT Product Name Application Type
VS-0425-FY158 Mouse Anti-RTN4 (clone 11C7) scFv-Fc Chimera ELISA, ICC Mouse IgG1, scFv-Fc
CAT Product Name Application Type
VS-0425-YC538 Recombinant Anti-RTN4 Vesicular Antibody, EV Displayed (VS-0425-YC538) ELISA, FC, Neut, Cell-uptake
Specific Inquiry
Go to compare Add to compare

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Go to compare

Go to compare