Anti-Human SPP1 Recombinant Antibody Fab Fragment (mAb 4-4-2) (CAT#: TAB-0258CL-F(E))
The anti-osteopontin antibodies target differen forms of Opn (full length, ThrOpn and MmpOpn), which has different functions in biomineralization, bone remodeling, immune function and heart. The anti-Opn antibody can be used in treatment and/or prevention of chronic inflammatory disease such as type-2 diabetes (T2D) and cardiovascular disease.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
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Figure 1 ELISA of mAbs against either full length Opn (flOpn), thrombin cleaved Opn (ThrOpn), or metalloproteinase cleaved Opn (MmpOpn).
mAb 4-4-2 shows exclusively binding to ThrOpn.
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Figure 2 Immunoreactivity of mAbs in Western Blot analysis against either flOpn (lane 1-4), ThrOpn (lane 5-6), or MmpOpn (lane 7-8).
mAb 4-4-2 shows a weak but exclusive binding to ThrOpn.
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Figure 3 Assessment of functional activity of mAbs.
(A) Cell adhesion induced by ThrOpn can just be blocked by mAb 21-5-4 mAb 4-4-2 although specific for ThrOpn does not appear to have inhibitory capacities in this setting. (B) Cell adhesion induced by MmpOpn can be blocked by mAbs more reactive towards MmpOpn such as mAb 7-5-4 and 9-3-1 and by the pan-reactive mAb 21-5-4.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- mAb 4-4-2
- Applications
- ELISA, WB, FuncS
- Related Disease
- Type-2 diabetes (T2D), cardiovascular disease
Applications
- Application Notes
- The antibody was validated for ELISA, Western blot and Function assay. For details, refer to Published Data.
Target
- Alternative Names
- SPP1; secreted phosphoprotein 1; OPN; BNSP; BSPI; ETA-1; osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
- Gene ID
- 6696
- UniProt ID
- A0A024RDE6
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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