Mouse Anti-TF Recombinant Antibody (clone JAA-F11); Fab Fragment (CAT#: PFBW-164)
Recombinant Mouse Antibody (JAA-F11) Fab Fragment is specific to TF antigen(Galβ1-3GalNAcα), expressed in Chinese Hamster Ovary cells (CHO). JAA-F11 preferentially binds to tumor tissue over normal, and in vivo it enhances survival and decreases metastasis in the mouse 4T1 metastatic model, indicating a potential for this mAb to be used, after humanization, in cancer patient therapy.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Liver
(Hepatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_4.jpg
(Hepatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_4.jpg
Figure 2 Kidney
(Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_5.jpg
(Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_5.jpg
Figure 3 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000091513-TF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000091513-TF
Figure 3 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091513-TF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091513-TF
Specifications
- Immunogen
- Human Thomsen-Friedenreich antigen (Galβ1-3GalNAcα)
- Host Species
- Mouse
- Type
- Mouse Fab
- Specificity
- Human TF
- Species Reactivity
- Human
- Clone
- JAA-F11
- Applications
- FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Galβ1-3GalNAcα; Thomsen-Friedenreich; TF
Related Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-121 | Mouse Anti-TF Recombinant Antibody (clone 5G9); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
| PSBC-122 | Human Anti-TF Recombinant Antibody (clone hATR-5); scFv Fragment | Block | Humanized scFv |
| HPAB-0232-YJ-S(P) | Rat Anti-TF Recombinant Antibody; scFv Fragment (HPAB-0232-YJ-S(P)) | ELISA, FuncS | Rat scFv |
| HPAB-0233-YJ-S(P) | Rat Anti-TF Recombinant Antibody; scFv Fragment (HPAB-0233-YJ-S(P)) | ELISA, FC, FuncS | Rat scFv |
| HPAB-0494-YJ-S(P) | Mouse Anti-TF Recombinant Antibody (clone CBT61YJ); scFv Fragment | ELISA, WB | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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