Recombinant Mouse Antibody (6A6) is capable of binding to TF, expressed in Chinese Hamster Ovary cells (CHO). This antibody is able to completely neutralize the anticoagulant activity of D3H44 in tissue factor-dependent functional assays, such as endotoxin-induced whole blood clotting, prothrombin time, as well as factor X and factor IX activation.
Figure 1 Binding of anti-TF antibodies to 6A6 coated on an ELISA plate.
Figure 2 Detection of anti-D3H44 antibodies in chimpanzees.
Chimpanzees were treated with D3H44-F(ab′)2 antibody. Plasma (citrated) samples were prepared from blood drawn before treatment with D3H44-F(ab′)2 antibody ("pre-treatment"), on day 21 and on day 43 post-treatment and analyzed for anti-D3H44 antibodies by competitive ELISA assay. 6A6 antibody or D3 antibody (control) were incubated with chimpanzee plasma and then the mixture was added to plates coated with D3H44-F(ab′)2 antibody. Bound chimpanzee antibodies were detected using anti-human Fc antibodies conjugated to horse radish peroxidase (HRP).
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-343 | Mouse Anti-TF Recombinant Antibody (clone 6A6); scFv Fragment | WB, ELISA, IF, FuncS | Mouse scFv |
PSBW-164 | Mouse Anti-TF Recombinant Antibody (clone JAA-F11); scFv Fragment | FuncS | Mouse scFv |
FAMAB-0318CQ-S(P) | Mouse Anti-TF Recombinant Antibody (clone PTF.02); scFv Fragment | ELISA, FC | Mouse scFv |
FAMAB-0319CQ-S(P) | Mouse Anti-TF Recombinant Antibody (clone TW4.20); scFv Fragment | ELISA, WB, FC, Inhib | Mouse scFv |
HPAB-0232-YJ-S(P) | Rat Anti-TF Recombinant Antibody; scFv Fragment (HPAB-0232-YJ-S(P)) | ELISA, FuncS | Rat scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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